Chromatographic comparison of bupivacaine imprinted polymers prepared in different formats: crushed monolith, microsphere, silica-based composite and capillary monolith formats

Peter Cormack, J. Oxelbark, C. Legido-Quigley, C.S.A. Aureliano, M.-M. Titirici, E. Schillinger, B. Sellergren, J. Courtois, K. Irgum, L. Dambies, P.A.G. Cormack, D.C. Sherrington and E. De Lorenzi

Research output: Contribution to journal › Article

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Abstract

A comprehensive comparison of five chromatographic stationary phases based on molecularly imprinted polymers is presented. Efficiency, imprinting factors, water compatibility and batch-to-batch reproducibility are discussed for crushed monolith, microspheres, two silica-based composites and capillary monoliths, all imprinted with the local anaesthetic bupivacaine. Synthesis protocol and chromatographic test conditions have been kept fixed within certain limits, in order to provide further insight into the strengths and weaknesses of the different formats. Excluding microparticles, all formats give satisfactory performance, especially in aqueous mobile phases. An assessment of batch-to-batch reproducibility in different mobile phases adds further value to this comparison study.
LanguageEnglish
Pages215-226
Number of pages12
JournalJournal of Chromatography A
DOIs
Publication statusPublished - 2007

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Bupivacaine
Local Anesthetics
Microspheres
Silicon Dioxide
Polymers
Water
Composite materials

Keywords

  • adsorption
  • bupivacaine
  • chromatography
  • microspheres
  • polymers
  • porosity silicon dioxide

Cite this

J. Oxelbark, C. Legido-Quigley, C.S.A. Aureliano, M.-M. Titirici, E. Schillinger, B. Sellergren, J. Courtois, K. Irgum, L. Dambies, P.A.G. Cormack, D.C. Sherrington and E. De Lorenzi (2007). Chromatographic comparison of bupivacaine imprinted polymers prepared in different formats: crushed monolith, microsphere, silica-based composite and capillary monolith formats. Journal of Chromatography A , 215-226. https://doi.org/10.1016/j.chroma.2007.05.057
J. Oxelbark, C. Legido-Quigley, C.S.A. Aureliano, M.-M. Titirici, E. Schillinger, B. Sellergren, J. Courtois, K. Irgum, L. Dambies, P.A.G. Cormack, D.C. Sherrington and E. De Lorenzi. / Chromatographic comparison of bupivacaine imprinted polymers prepared in different formats: crushed monolith, microsphere, silica-based composite and capillary monolith formats. In: Journal of Chromatography A . 2007 ; pp. 215-226.
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J. Oxelbark, C. Legido-Quigley, C.S.A. Aureliano, M.-M. Titirici, E. Schillinger, B. Sellergren, J. Courtois, K. Irgum, L. Dambies, P.A.G. Cormack, D.C. Sherrington and E. De Lorenzi 2007, 'Chromatographic comparison of bupivacaine imprinted polymers prepared in different formats: crushed monolith, microsphere, silica-based composite and capillary monolith formats' Journal of Chromatography A , pp. 215-226. https://doi.org/10.1016/j.chroma.2007.05.057

Chromatographic comparison of bupivacaine imprinted polymers prepared in different formats: crushed monolith, microsphere, silica-based composite and capillary monolith formats. / J. Oxelbark, C. Legido-Quigley, C.S.A. Aureliano, M.-M. Titirici, E. Schillinger, B. Sellergren, J. Courtois, K. Irgum, L. Dambies, P.A.G. Cormack, D.C. Sherrington and E. De Lorenzi.

In: Journal of Chromatography A , 2007, p. 215-226.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Chromatographic comparison of bupivacaine imprinted polymers prepared in different formats: crushed monolith, microsphere, silica-based composite and capillary monolith formats

AU - Cormack, Peter

AU - J. Oxelbark, C. Legido-Quigley, C.S.A. Aureliano, M.-M. Titirici, E. Schillinger, B. Sellergren, J. Courtois, K. Irgum, L. Dambies, P.A.G. Cormack, D.C. Sherrington and E. De Lorenzi

PY - 2007

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N2 - A comprehensive comparison of five chromatographic stationary phases based on molecularly imprinted polymers is presented. Efficiency, imprinting factors, water compatibility and batch-to-batch reproducibility are discussed for crushed monolith, microspheres, two silica-based composites and capillary monoliths, all imprinted with the local anaesthetic bupivacaine. Synthesis protocol and chromatographic test conditions have been kept fixed within certain limits, in order to provide further insight into the strengths and weaknesses of the different formats. Excluding microparticles, all formats give satisfactory performance, especially in aqueous mobile phases. An assessment of batch-to-batch reproducibility in different mobile phases adds further value to this comparison study.

AB - A comprehensive comparison of five chromatographic stationary phases based on molecularly imprinted polymers is presented. Efficiency, imprinting factors, water compatibility and batch-to-batch reproducibility are discussed for crushed monolith, microspheres, two silica-based composites and capillary monoliths, all imprinted with the local anaesthetic bupivacaine. Synthesis protocol and chromatographic test conditions have been kept fixed within certain limits, in order to provide further insight into the strengths and weaknesses of the different formats. Excluding microparticles, all formats give satisfactory performance, especially in aqueous mobile phases. An assessment of batch-to-batch reproducibility in different mobile phases adds further value to this comparison study.

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KW - porosity silicon dioxide

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J. Oxelbark, C. Legido-Quigley, C.S.A. Aureliano, M.-M. Titirici, E. Schillinger, B. Sellergren, J. Courtois, K. Irgum, L. Dambies, P.A.G. Cormack, D.C. Sherrington and E. De Lorenzi. Chromatographic comparison of bupivacaine imprinted polymers prepared in different formats: crushed monolith, microsphere, silica-based composite and capillary monolith formats. Journal of Chromatography A . 2007;215-226. https://doi.org/10.1016/j.chroma.2007.05.057

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