Chitosan derivatives alter release profiles of model compounds from calcium phosphate implants

S Green, M Roldo, D Douroumis, N Bouropoulos, D Lamprou, D G Fatouros

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The aim of the current study was to evaluate the impact of chitosan derivatives, namely N-octyl-chitosan and N-octyl-O-sulfate chitosan, incorporated in calcium phosphate implants to the release profiles of model drugs. The rate and extent of calcein (on M.W. 650 Da) ED, and FITC-dextran (M.W. 40 kDa) on in vitro release were monitored by fluorescence spectroscopy. Results show that calcein release is affected by the type of chitosan derivative used. A higher percentage of model drug was released when the hydrophilic polymer N-octyl-sulfated chitosan was present in the tablets compared with the tablets containing the hydrophobic polymer N-octyl-chitosan. The release profiles of calcein or FD from tablets containing N-octyl-O-sulfate revealed a complete release for FD after 120 h compared with calcein where 20% of the drug was released over the same time period. These results suggest that the difference in the release profiles observed from the implants is dependent on the molecular weight of the model drugs. These data indicate the potential of chitosan derivatives in controlling the release profile of active compounds from calcium phosphate implants.
LanguageEnglish
Pages901-907
Number of pages7
JournalCarbohydrate Research
Volume344
Issue number7
DOIs
Publication statusPublished - 12 May 2009

Fingerprint

Chitosan
Derivatives
Tablets
Pharmaceutical Preparations
Polymers
Fluorescence spectroscopy
Molecular Models
Fluorescence Spectrometry
Sulfates
Dextrans
Molecular weight
calcium phosphate
Molecular Weight
fluorexon

Keywords

  • Chitosan derivatives
  • hydroxyapatite
  • calcium phosphate implants
  • calcein
  • FITC-dextran

Cite this

Green, S., Roldo, M., Douroumis, D., Bouropoulos, N., Lamprou, D., & Fatouros, D. G. (2009). Chitosan derivatives alter release profiles of model compounds from calcium phosphate implants. Carbohydrate Research, 344(7), 901-907. https://doi.org/10.1016/j.carres.2009.02.022
Green, S ; Roldo, M ; Douroumis, D ; Bouropoulos, N ; Lamprou, D ; Fatouros, D G. / Chitosan derivatives alter release profiles of model compounds from calcium phosphate implants. In: Carbohydrate Research. 2009 ; Vol. 344, No. 7. pp. 901-907.
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Green, S, Roldo, M, Douroumis, D, Bouropoulos, N, Lamprou, D & Fatouros, DG 2009, 'Chitosan derivatives alter release profiles of model compounds from calcium phosphate implants' Carbohydrate Research, vol. 344, no. 7, pp. 901-907. https://doi.org/10.1016/j.carres.2009.02.022

Chitosan derivatives alter release profiles of model compounds from calcium phosphate implants. / Green, S; Roldo, M; Douroumis, D; Bouropoulos, N; Lamprou, D; Fatouros, D G.

In: Carbohydrate Research, Vol. 344, No. 7, 12.05.2009, p. 901-907.

Research output: Contribution to journalArticle

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