Chemometrics: implementing multivariate data analysis to monitor mammalian cell culture processes

Payal Roychoudhury, Ronan O'Kennedy, Jim Faulkner, Brian McNeil, Linda M. Harvey

Research output: Contribution to journalArticle

Abstract

Biopharmaceutical companies are constantly evaluating new methods for mammalian cell line development that offer benefits such as shorter time lines, improved consistency, higher monoclonal antibody (mAb) production, better genetic stability and increased flexibility. Each of these advantages extends a potentially large cost benefit to companies as their recombinant protein products move from development into the clinic, and finally on to commercial launch1. In this context, sophisticated chemometric software packages show great potential in enhancing process knowledge and providing optimised control of these complex and challenging processes.

LanguageEnglish
Pages15-20
Number of pages6
JournalEuropean Pharmaceutical Review
Volume18
Issue number3
Publication statusPublished - 13 Jun 2013

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Cell culture
Recombinant Proteins
Cost-Benefit Analysis
Antibody Formation
Software
Multivariate Analysis
Cell Culture Techniques
Monoclonal Antibodies
Cell Line
Software packages
Industry
Cells
Costs

Keywords

  • mammalian cell line
  • multivariate data analysis
  • fault diagnosis

Cite this

Roychoudhury, Payal ; O'Kennedy, Ronan ; Faulkner, Jim ; McNeil, Brian ; Harvey, Linda M. / Chemometrics : implementing multivariate data analysis to monitor mammalian cell culture processes. In: European Pharmaceutical Review. 2013 ; Vol. 18, No. 3. pp. 15-20.
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Roychoudhury, P, O'Kennedy, R, Faulkner, J, McNeil, B & Harvey, LM 2013, 'Chemometrics: implementing multivariate data analysis to monitor mammalian cell culture processes' European Pharmaceutical Review, vol. 18, no. 3, pp. 15-20.

Chemometrics : implementing multivariate data analysis to monitor mammalian cell culture processes. / Roychoudhury, Payal; O'Kennedy, Ronan; Faulkner, Jim; McNeil, Brian; Harvey, Linda M.

In: European Pharmaceutical Review, Vol. 18, No. 3, 13.06.2013, p. 15-20.

Research output: Contribution to journalArticle

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