Chemical functionalisation and geometrical modification of cellulose fibrous networks for tissue engineering

Stephen J. Eichhorn, Julie E. Gough, Rein V. Ulijn, William W. Sampson, Deepak Kalaskar, Shijie Cai

Research output: Contribution to conferenceAbstract

Abstract

The use of chemically modified cellulose fibrous networks for the binding and proliferation of fibroblast cells is reported. Specifically the use of glycine and fmoc-proteced glycine groups to promote cell adhesion to the fibre surfaces and to enable proliferation in the porous structures of the networks respectively is presented. The geometry, including control of the pore size and porosity, is also presented as a means to control the proliferation and cell morphology. The cell morphologies are reported using Scanning Electron Microscopy and an MTT assay is presented to show the proliferation rates of the cells. Results from Confocal Laser Scanning Microscopy with specific collagen and cell-nucleus staining is also reported to highlight the efficacy of chemical treatments
Original languageEnglish
Number of pages1
Publication statusPublished - 26 Mar 2006
Event231st ACS National Meeting - Atlanta, GA, United States
Duration: 26 Mar 200630 Mar 2006

Conference

Conference231st ACS National Meeting
CountryUnited States
CityAtlanta, GA
Period26/03/0630/03/06

Keywords

  • chemical functionalisation
  • geometrical modification
  • cellulose fibrous networks
  • tissue engineering

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