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Impurity profiling of seized methamphetamine can provide very useful information in criminal investigations and, specifically, on drug trafficking routes, sources of supply, and relationships between seizures. Particularly important is the identification of 'route specific' impurities or those which indicate the synthetic method used for manufacture in illicit laboratories. Previous researchers 1-2 have suggested impurities which are characteristic of the Leuckart and reductive amination (Al/Hg) methods of preparation. However, to date and importantly, these two synthetic methods have not been compared in a single study utilizing methamphetamine hydrochloride synthesised in-house and, therefore, of known synthetic origin. Using the same starting material, 1-phenyl-2-propanone (P2P), 40 batches of methamphetamine hydrochloride were synthesised by the Leuckart and reductive amination methods (20 batches per method). Both basic and acidic impurities were extracted separately and analysed by GC-MS. From this controlled study, two route specific impurities for the Leuckart method and one route specific impurity for the reductive amination method are reported. The intra- and inter-batch variation of these route specific impurities was assessed. Also, the variation of the 'target impurities' recently recommended for methamphetamine profiling is discussed in relation to their variation within and between production batches synthesized using the Leuckart and reductive amination routes.
|Number of pages||7|
|Early online date||28 Jul 2009|
|Publication status||Published - 1 Sept 2009|
- route specific impurities
- reductive amination methods
- analtical chemistry
FingerprintDive into the research topics of 'Characterization of route specific impurities found in methamphetamine synthesized by the Leuckart and reductive amination methods'. Together they form a unique fingerprint.
- 1 Finished
Isotope Profiling of Drugs: A Tool to Disrupt Organised Crime, Detect Serious Crime and Reduce Volume Crime
Nic Daeid, N. & Fraser, J.
EPSRC (Engineering and Physical Sciences Research Council)
1/02/06 → 31/03/09
Illicit drug analysis as a tool to combat global organised crime
Niamh Nic Daeid (Participant), David Littlejohn (Participant), William Kerr (Participant), Oliver Brook Sutcliffe (Participant), Katy Savage (Participant) & W. Meier-Augenstein (Participant)
Impact: Impact - for External Portal › Quality of life and safety, Economic and commerce, Professional practice, training and standardsFile