Characterisation of niosome nanoparticles prepared by microfluidic mixing for drug delivery

Mohammad A. Obeid, Ibrahim Khadra, Alaa A.A. Aljabali, Haneen Amawi, Valerie A. Ferro

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
25 Downloads (Pure)

Abstract

Lipid nanoparticles have gained much attention due to their potential as drug delivery systems. They are safe, effective, and be targeted to particular tissues to deliver their payload. Niosomes are one type of lipid nanoparticles that comprise non-ionic surfactants which have proven to be effective due to their stability and biocompatibility. Different manufacturing processes have been reported for niosome preparation, but many of them are not scalable or reproducible for pharmaceutical use. In this study, microfluidic mixing was used to prepare niosomes with different lipid compositions by changing the type of non-ionic surfactant. Niosomes were evaluated for their physicochemical characteristics, morphology, encapsulation efficacy, release profiles of atenolol as a model hydrophilic compound, and cytotoxic activities. Microfluidic mixing allows for particle self-assembly and drug loading in a single step, without the need for post-preparation size reduction. Depending on the lipid composition, the empty particles were
Original languageEnglish
Article number100137
Number of pages7
JournalInternational Journal of Pharmaceutics: X
Volume4
Early online date1 Nov 2022
DOIs
Publication statusPublished - 31 Dec 2022

Keywords

  • niosomes
  • drug delivery
  • microfluidic mixing
  • atenolol
  • drug release

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