Characterisation of microstructural changes during the hydration of pharmaceutical tablets using terahertz pulsed imaging

Daniel Markl, Samy Yassin, Parry Wang, J. Axel Zeitler

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

Abstract

Terahertz pulsed imaging (TPI) is used to characterise microstructural changes during the hydration of pharmaceutical tablets. In particular, terahertz reflection measurements provide quantitative information about the liquid penetration, swelling and the formation of cracks. X-ray computed microtomography (XμCT) is employed to characterise the microstructure of the dry powder compact in terms of porosity, equivalent volume diameter and length of the pores. Both XμCT and TPI can provide valuable information about the impact of the microstructure on the performance of drugs.

Original languageEnglish
Title of host publication41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016
Volume2016-November
DOIs
Publication statusPublished - 1 Dec 2016
Event41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016 - Bella Center, Copenhagen, Denmark
Duration: 25 Sep 201630 Sep 2016
http://terahertz.dk/irmmwthz2016/
http://www.irmmw-thz2016.org/

Conference

Conference41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016
Abbreviated titleIRMMW-THz 2016
CountryDenmark
CityCopenhagen
Period25/09/1630/09/16
Internet address

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Keywords

  • pharmaceutical tabletsmicrostructural changes
  • microstructural changes
  • hydration
  • terahertz

Cite this

Markl, D., Yassin, S., Wang, P., & Zeitler, J. A. (2016). Characterisation of microstructural changes during the hydration of pharmaceutical tablets using terahertz pulsed imaging. In 41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016 (Vol. 2016-November). [7758451] https://doi.org/10.1109/IRMMW-THz.2016.7758451