Characterisation of microstructural changes during the hydration of pharmaceutical tablets using terahertz pulsed imaging

Daniel Markl; Samy Yassin; Parry Wang; J. Axel Zeitler

doi:10.1109/IRMMW-THz.2016.7758451

Characterisation of microstructural changes during the hydration of pharmaceutical tablets using terahertz pulsed imaging

Daniel Markl, Samy Yassin, Parry Wang, J. Axel Zeitler

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

Abstract

Terahertz pulsed imaging (TPI) is used to characterise microstructural changes during the hydration of pharmaceutical tablets. In particular, terahertz reflection measurements provide quantitative information about the liquid penetration, swelling and the formation of cracks. X-ray computed microtomography (XμCT) is employed to characterise the microstructure of the dry powder compact in terms of porosity, equivalent volume diameter and length of the pores. Both XμCT and TPI can provide valuable information about the impact of the microstructure on the performance of drugs.

Original language	English
Title of host publication	41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016
Volume	2016-November
DOIs	https://doi.org/10.1109/IRMMW-THz.2016.7758451
Publication status	Published - 1 Dec 2016
Event	41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016 - Bella Center, Copenhagen, Denmark Duration: 25 Sep 2016 → 30 Sep 2016 http://terahertz.dk/irmmwthz2016/ http://www.irmmw-thz2016.org/

Conference

Conference	41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016
Abbreviated title	IRMMW-THz 2016
Country	Denmark
City	Copenhagen
Period	25/09/16 → 30/09/16
Internet address	http://terahertz.dk/irmmwthz2016/ http://www.irmmw-thz2016.org/

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Keywords

pharmaceutical tabletsmicrostructural changes
microstructural changes
hydration
terahertz

Cite this

Markl, D., Yassin, S., Wang, P., & Zeitler, J. A. (2016). Characterisation of microstructural changes during the hydration of pharmaceutical tablets using terahertz pulsed imaging. In 41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016 (Vol. 2016-November). [7758451] https://doi.org/10.1109/IRMMW-THz.2016.7758451

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Markl, D, Yassin, S, Wang, P & Zeitler, JA 2016, Characterisation of microstructural changes during the hydration of pharmaceutical tablets using terahertz pulsed imaging. in 41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016. vol. 2016-November, 7758451, 41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016, Copenhagen, Denmark, 25/09/16. https://doi.org/10.1109/IRMMW-THz.2016.7758451

Characterisation of microstructural changes during the hydration of pharmaceutical tablets using terahertz pulsed imaging. / Markl, Daniel; Yassin, Samy; Wang, Parry; Zeitler, J. Axel.

41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016. Vol. 2016-November 2016. 7758451.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

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Access to Document

10.1109/IRMMW-THz.2016.7758451

Link to publication in Scopus