Characterisation of microstructural changes during the hydration of pharmaceutical tablets using terahertz pulsed imaging

Daniel Markl; Samy Yassin; Parry Wang; J. Axel Zeitler

doi:10.1109/IRMMW-THz.2016.7758451

Characterisation of microstructural changes during the hydration of pharmaceutical tablets using terahertz pulsed imaging

Daniel Markl, Samy Yassin, Parry Wang, J. Axel Zeitler

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

Abstract

Terahertz pulsed imaging (TPI) is used to characterise microstructural changes during the hydration of pharmaceutical tablets. In particular, terahertz reflection measurements provide quantitative information about the liquid penetration, swelling and the formation of cracks. X-ray computed microtomography (XμCT) is employed to characterise the microstructure of the dry powder compact in terms of porosity, equivalent volume diameter and length of the pores. Both XμCT and TPI can provide valuable information about the impact of the microstructure on the performance of drugs.

Original language	English
Title of host publication	41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016
Volume	2016-November
DOIs	https://doi.org/10.1109/IRMMW-THz.2016.7758451
Publication status	Published - 1 Dec 2016
Event	41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016 - Bella Center, Copenhagen, Denmark Duration: 25 Sep 2016 → 30 Sep 2016 http://terahertz.dk/irmmwthz2016/ http://www.irmmw-thz2016.org/

Conference

Conference	41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016
Abbreviated title	IRMMW-THz 2016
Country	Denmark
City	Copenhagen
Period	25/09/16 → 30/09/16
Internet address	http://terahertz.dk/irmmwthz2016/ http://www.irmmw-thz2016.org/

Keywords

pharmaceutical tabletsmicrostructural changes
microstructural changes
hydration
terahertz

Access to Document

10.1109/IRMMW-THz.2016.7758451

Link to publication in Scopus

Fingerprint Dive into the research topics of 'Characterisation of microstructural changes during the hydration of pharmaceutical tablets using terahertz pulsed imaging'. Together they form a unique fingerprint.

Cite this

@inproceedings{65ab8aba6ccb43eb841561ec1e7c3725,

title = "Characterisation of microstructural changes during the hydration of pharmaceutical tablets using terahertz pulsed imaging",

abstract = "Terahertz pulsed imaging (TPI) is used to characterise microstructural changes during the hydration of pharmaceutical tablets. In particular, terahertz reflection measurements provide quantitative information about the liquid penetration, swelling and the formation of cracks. X-ray computed microtomography (XμCT) is employed to characterise the microstructure of the dry powder compact in terms of porosity, equivalent volume diameter and length of the pores. Both XμCT and TPI can provide valuable information about the impact of the microstructure on the performance of drugs.",

keywords = "pharmaceutical tabletsmicrostructural changes, microstructural changes, hydration, terahertz",

author = "Daniel Markl and Samy Yassin and Parry Wang and Zeitler, {J. Axel}",

year = "2016",

month = dec,

day = "1",

doi = "10.1109/IRMMW-THz.2016.7758451",

language = "English",

volume = "2016-November",

booktitle = "41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016",

note = "41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016, IRMMW-THz 2016 ; Conference date: 25-09-2016 Through 30-09-2016",

url = "http://terahertz.dk/irmmwthz2016/, http://www.irmmw-thz2016.org/",

}

Markl, D, Yassin, S, Wang, P & Zeitler, JA 2016, Characterisation of microstructural changes during the hydration of pharmaceutical tablets using terahertz pulsed imaging. in 41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016. vol. 2016-November, 7758451, 41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016, Copenhagen, Denmark, 25/09/16. https://doi.org/10.1109/IRMMW-THz.2016.7758451

Characterisation of microstructural changes during the hydration of pharmaceutical tablets using terahertz pulsed imaging. / Markl, Daniel; Yassin, Samy; Wang, Parry; Zeitler, J. Axel.

41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016. Vol. 2016-November 2016. 7758451.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

TY - GEN

T1 - Characterisation of microstructural changes during the hydration of pharmaceutical tablets using terahertz pulsed imaging

AU - Markl, Daniel

AU - Yassin, Samy

AU - Wang, Parry

AU - Zeitler, J. Axel

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Terahertz pulsed imaging (TPI) is used to characterise microstructural changes during the hydration of pharmaceutical tablets. In particular, terahertz reflection measurements provide quantitative information about the liquid penetration, swelling and the formation of cracks. X-ray computed microtomography (XμCT) is employed to characterise the microstructure of the dry powder compact in terms of porosity, equivalent volume diameter and length of the pores. Both XμCT and TPI can provide valuable information about the impact of the microstructure on the performance of drugs.

AB - Terahertz pulsed imaging (TPI) is used to characterise microstructural changes during the hydration of pharmaceutical tablets. In particular, terahertz reflection measurements provide quantitative information about the liquid penetration, swelling and the formation of cracks. X-ray computed microtomography (XμCT) is employed to characterise the microstructure of the dry powder compact in terms of porosity, equivalent volume diameter and length of the pores. Both XμCT and TPI can provide valuable information about the impact of the microstructure on the performance of drugs.

KW - pharmaceutical tabletsmicrostructural changes

KW - microstructural changes

KW - hydration

KW - terahertz

UR - http://www.scopus.com/inward/record.url?scp=85006110299&partnerID=8YFLogxK

U2 - 10.1109/IRMMW-THz.2016.7758451

DO - 10.1109/IRMMW-THz.2016.7758451

M3 - Conference contribution book

AN - SCOPUS:85006110299

VL - 2016-November

BT - 41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016

T2 - 41st International Conference on Infrared, Millimeter and Terahertz Waves, IRMMW-THz 2016

Y2 - 25 September 2016 through 30 September 2016

ER -