Characterisation of amorphous and nanocrystalline molecular materials by total scattering

Simon J L Billinge; Timur Dykhne; Pavol Juhas; Emil Bozin; Ryan Taylor; Alastair Florence; Kenneth Shankland

doi:10.1039/b915453a

Characterisation of amorphous and nanocrystalline molecular materials by total scattering

Simon J L Billinge, Timur Dykhne, Pavol Juhas, Emil Bozin, Ryan Taylor, Alastair Florence, Kenneth Shankland

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

137 Downloads (Pure)

Abstract

The use of high-energy X-ray total scattering coupled with pair distribution function analysis produces unique structural fingerprints from amorphous and nanostructured phases of the pharmaceuticalscarbamazepine and indomethacin. The advantages of such facility-based experiments over laboratory-based ones are discussed and the technique is illustrated with the characterisation of a melt-quenched sample of carbamazepine as a nanocrystalline (4.5 nm domain diameter) version of form III.

Original language	English
Pages (from-to)	1366-1368
Number of pages	3
Journal	CrystEngComm
Volume	12
Issue number	5
Early online date	19 Oct 2009
DOIs	https://doi.org/10.1039/b915453a
Publication status	Published - 2010

Keywords

nanocrystalline molecular materials
crystals
x-rays
scattering

Access to Document

10.1039/b915453a

B915453aFinal published version, 181 KB

Fingerprint Dive into the research topics of 'Characterisation of amorphous and nanocrystalline molecular materials by total scattering'. Together they form a unique fingerprint.

1 Finished

Physical Organic Chemistry: Opportunities In Synthesis, Materials And Pharmaceuticals (Science And Innovation Award)
Murphy, J., Coombs, G., Ferguson, A. & Florence, A.
Scottish Funding Council SFC, EPSRC (Engineering and Physical Sciences Research Council)
1/09/07 → 30/10/12
Project: Research

Cite this

@article{1964ff8522664555828b013f6bb9bf4a,

title = "Characterisation of amorphous and nanocrystalline molecular materials by total scattering",

abstract = "The use of high-energy X-ray total scattering coupled with pair distribution function analysis produces unique structural fingerprints from amorphous and nanostructured phases of the pharmaceuticalscarbamazepine and indomethacin. The advantages of such facility-based experiments over laboratory-based ones are discussed and the technique is illustrated with the characterisation of a melt-quenched sample of carbamazepine as a nanocrystalline (4.5 nm domain diameter) version of form III. ",

keywords = "nanocrystalline molecular materials , crystals, x-rays , scattering",

author = "Billinge, {Simon J L} and Timur Dykhne and Pavol Juhas and Emil Bozin and Ryan Taylor and Alastair Florence and Kenneth Shankland",

year = "2010",

doi = "10.1039/b915453a",

language = "English",

volume = "12",

pages = "1366--1368",

journal = "CrystEngComm",

issn = "1466-8033",

publisher = "Royal Society of Chemistry",

number = "5",

}

TY - JOUR

T1 - Characterisation of amorphous and nanocrystalline molecular materials by total scattering

AU - Billinge, Simon J L

AU - Dykhne, Timur

AU - Juhas, Pavol

AU - Bozin, Emil

AU - Taylor, Ryan

AU - Florence, Alastair

AU - Shankland, Kenneth

PY - 2010

Y1 - 2010

N2 - The use of high-energy X-ray total scattering coupled with pair distribution function analysis produces unique structural fingerprints from amorphous and nanostructured phases of the pharmaceuticalscarbamazepine and indomethacin. The advantages of such facility-based experiments over laboratory-based ones are discussed and the technique is illustrated with the characterisation of a melt-quenched sample of carbamazepine as a nanocrystalline (4.5 nm domain diameter) version of form III.

AB - The use of high-energy X-ray total scattering coupled with pair distribution function analysis produces unique structural fingerprints from amorphous and nanostructured phases of the pharmaceuticalscarbamazepine and indomethacin. The advantages of such facility-based experiments over laboratory-based ones are discussed and the technique is illustrated with the characterisation of a melt-quenched sample of carbamazepine as a nanocrystalline (4.5 nm domain diameter) version of form III.

KW - nanocrystalline molecular materials

KW - crystals

KW - x-rays

KW - scattering

U2 - 10.1039/b915453a

DO - 10.1039/b915453a

M3 - Article

VL - 12

SP - 1366

EP - 1368

JO - CrystEngComm

JF - CrystEngComm

SN - 1466-8033

IS - 5

ER -

Characterisation of amorphous and nanocrystalline molecular materials by total scattering

Abstract

Keywords

Access to Document

Physical Organic Chemistry: Opportunities In Synthesis, Materials And Pharmaceuticals (Science And Innovation Award)

Cite this