The use of high-energy X-ray total scattering coupled with pair distribution function analysis produces unique structural fingerprints from amorphous and nanostructured phases of the pharmaceuticalscarbamazepine and indomethacin. The advantages of such facility-based experiments over laboratory-based ones are discussed and the technique is illustrated with the characterisation of a melt-quenched sample of carbamazepine as a nanocrystalline (4.5 nm domain diameter) version of form III.
- nanocrystalline molecular materials
Billinge, S. J. L., Dykhne, T., Juhas, P., Bozin, E., Taylor, R., Florence, A., & Shankland, K. (2010). Characterisation of amorphous and nanocrystalline molecular materials by total scattering. CrystEngComm, 12(5), 1366-1368. https://doi.org/10.1039/b915453a