Characterisation of amorphous and nanocrystalline molecular materials by total scattering

Simon J L Billinge, Timur Dykhne, Pavol Juhas, Emil Bozin, Ryan Taylor, Alastair Florence, Kenneth Shankland

Research output: Contribution to journal › Article

50 Citations (Scopus)

Abstract

The use of high-energy X-ray total scattering coupled with pair distribution function analysis produces unique structural fingerprints from amorphous and nanostructured phases of the pharmaceuticalscarbamazepine and indomethacin. The advantages of such facility-based experiments over laboratory-based ones are discussed and the technique is illustrated with the characterisation of a melt-quenched sample of carbamazepine as a nanocrystalline (4.5 nm domain diameter) version of form III.


LanguageEnglish
Pages1366-1368
Number of pages3
JournalCrystEngComm
Volume12
Issue number5
Early online date19 Oct 2009
DOIs
Publication statusPublished - 2010

Fingerprint

Carbamazepine
Indomethacin
Distribution functions
distribution functions
Scattering
X rays
scattering
x rays
Experiments
energy

Keywords

  • nanocrystalline molecular materials
  • crystals
  • x-rays
  • scattering

Cite this

Billinge, S. J. L., Dykhne, T., Juhas, P., Bozin, E., Taylor, R., Florence, A., & Shankland, K. (2010). Characterisation of amorphous and nanocrystalline molecular materials by total scattering. CrystEngComm, 12(5), 1366-1368. https://doi.org/10.1039/b915453a
Billinge, Simon J L ; Dykhne, Timur ; Juhas, Pavol ; Bozin, Emil ; Taylor, Ryan ; Florence, Alastair ; Shankland, Kenneth. / Characterisation of amorphous and nanocrystalline molecular materials by total scattering. In: CrystEngComm. 2010 ; Vol. 12, No. 5. pp. 1366-1368.
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Billinge, SJL, Dykhne, T, Juhas, P, Bozin, E, Taylor, R, Florence, A & Shankland, K 2010, 'Characterisation of amorphous and nanocrystalline molecular materials by total scattering' CrystEngComm, vol. 12, no. 5, pp. 1366-1368. https://doi.org/10.1039/b915453a

Characterisation of amorphous and nanocrystalline molecular materials by total scattering. / Billinge, Simon J L; Dykhne, Timur; Juhas, Pavol; Bozin, Emil; Taylor, Ryan; Florence, Alastair; Shankland, Kenneth.

In: CrystEngComm, Vol. 12, No. 5, 2010, p. 1366-1368.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Characterisation of amorphous and nanocrystalline molecular materials by total scattering

AU - Billinge, Simon J L

AU - Dykhne, Timur

AU - Juhas, Pavol

AU - Bozin, Emil

AU - Taylor, Ryan

AU - Florence, Alastair

AU - Shankland, Kenneth

PY - 2010

Y1 - 2010

N2 - The use of high-energy X-ray total scattering coupled with pair distribution function analysis produces unique structural fingerprints from amorphous and nanostructured phases of the pharmaceuticalscarbamazepine and indomethacin. The advantages of such facility-based experiments over laboratory-based ones are discussed and the technique is illustrated with the characterisation of a melt-quenched sample of carbamazepine as a nanocrystalline (4.5 nm domain diameter) version of form III.

AB - The use of high-energy X-ray total scattering coupled with pair distribution function analysis produces unique structural fingerprints from amorphous and nanostructured phases of the pharmaceuticalscarbamazepine and indomethacin. The advantages of such facility-based experiments over laboratory-based ones are discussed and the technique is illustrated with the characterisation of a melt-quenched sample of carbamazepine as a nanocrystalline (4.5 nm domain diameter) version of form III.

KW - nanocrystalline molecular materials

KW - crystals

KW - x-rays

KW - scattering

U2 - 10.1039/b915453a

DO - 10.1039/b915453a

M3 - Article

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EP - 1368

JO - CrystEngComm

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JF - CrystEngComm

SN - 1466-8033

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Billinge SJL, Dykhne T, Juhas P, Bozin E, Taylor R, Florence A et al. Characterisation of amorphous and nanocrystalline molecular materials by total scattering. CrystEngComm. 2010;12(5):1366-1368. https://doi.org/10.1039/b915453a

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