Changes to inhaled corticosteroid dose when initiating combination inhaler therapy in long-acting β agonist-naive patients with asthma: a retrospective database analysis

Jordan R Covvey, Blair F Johnston, Fraser Wood, Anne C Boyter

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Retrospective prescribing data were obtained from 46 general practice surgeries in NHS Scotland. Patients with asthma who were naïve to previous long-acting β agonist therapy and initiated combination inhaler therapy in 2008–2009 were classified according to the inhaled corticosteroid (ICS) dose in their combination inhaler compared with the highest dose of ICS they received before initiation. Among the 685 patients (541 (79.0%) who had been prescribed an ICS previously), those originally on low-, medium- or high-dose ICS were changed to high-dose combination therapy in 122/250 (48.8%), 94/151 (62.3%) or 85/113 (75.2%) cases in each ICS dose category, respectively. These results suggest that evaluation of appropriate high-dose ICS prescribing in general practice is needed.
Original languageEnglish
Pages (from-to)1056 - 1058
Number of pages3
Issue number11
Early online date15 Jan 2014
Publication statusPublished - Nov 2014


  • inhaled corticosteroid dose
  • combination inhaler therapy
  • long-acting
  • β agonist-naïve patients
  • asthma
  • retrospective
  • database analysis

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