Changes in primary metabolism leading to citric acid overflow in aspergillus niger

Matic Legisa, Michael Mattey

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For citric acid-accumulating Aspergillus niger cells, the enhancement of anaplerotic reactions replenishing tricarboxylic acid cycle intermediates predisposes the cells to form the product. However, there is no increased citrate level in germinating spores and a complex sequence of developmental events is needed to change the metabolism in a way that leads to an increased level of tricarboxylic acid cycle intermediates in mycelia. A review of physiological events that cause such intracellular conditions, with the special emphasis on the discussion of hexose transport into the cells and regulation of primary metabolism, predominantly of glycolytic flux during the process, is presented.
Original languageEnglish
Pages (from-to)181-190
Number of pages10
JournalBiotechnology Letters
Issue number2
Publication statusPublished - 2007



  • anaplerosis
  • aspergillus niger
  • citric acid
  • hexose transport
  • primary metabolism

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