Changes in primary metabolism leading to citric acid overflow in aspergillus niger

Matic Legisa, Michael Mattey

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

For citric acid-accumulating Aspergillus niger cells, the enhancement of anaplerotic reactions replenishing tricarboxylic acid cycle intermediates predisposes the cells to form the product. However, there is no increased citrate level in germinating spores and a complex sequence of developmental events is needed to change the metabolism in a way that leads to an increased level of tricarboxylic acid cycle intermediates in mycelia. A review of physiological events that cause such intracellular conditions, with the special emphasis on the discussion of hexose transport into the cells and regulation of primary metabolism, predominantly of glycolytic flux during the process, is presented.
LanguageEnglish
Pages181-190
Number of pages10
JournalBiotechnology Letters
Volume29
Issue number2
DOIs
Publication statusPublished - 2007

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Aspergillus niger
Citric Acid
Citric Acid Cycle
Hexoses
Mycelium
Spores

Keywords

  • anaplerosis
  • aspergillus niger
  • citric acid
  • hexose transport
  • primary metabolism

Cite this

Legisa, Matic ; Mattey, Michael. / Changes in primary metabolism leading to citric acid overflow in aspergillus niger. In: Biotechnology Letters. 2007 ; Vol. 29, No. 2. pp. 181-190.
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Changes in primary metabolism leading to citric acid overflow in aspergillus niger. / Legisa, Matic; Mattey, Michael.

In: Biotechnology Letters, Vol. 29, No. 2, 2007, p. 181-190.

Research output: Contribution to journalArticle

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T1 - Changes in primary metabolism leading to citric acid overflow in aspergillus niger

AU - Legisa, Matic

AU - Mattey, Michael

PY - 2007

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KW - hexose transport

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JF - Biotechnology Letters

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