Changes in cerebal vascular reactivity occur early during cardiopulmonary bypass in the rat

T. Modine, R. Azzaoui, T. Ouk, G. Fayad, D. Lacroix, H. Warembourg, R. Bordet, T. Gourlay

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Cardiopulmonary bypass (CPB) is known to cause cerebrovascular dysfunction. The etiology of these complications is complex, but disruption of normal cerebral endothelial function as a consequence of inflammatory or hypoperfusion phenomena have been implicated. The aim of this study was to investigate the effect of CPB time on cerebrovascular reactivity and to investigate the correlation of these findings with measured inflammatory markers. Cerebrovascular impairment appears early after the onset of CPB. The specific loss of acetylcholine-induced vasodilation suggests endothelial cell dysfunction rather than impaired vascular smooth muscle response to nitric oxide. This loss of endothelium-dependent regulatory factors after CPB may enhance vasoconstriction, impair cerebrovascular function, and contribute to neurologic injury after CPB.
    Original languageEnglish
    Pages (from-to)672-678
    Number of pages6
    JournalAnnals of Thoracic Surgery
    Volume82
    DOIs
    Publication statusPublished - 2006

    Fingerprint

    Cardiopulmonary Bypass
    Blood Vessels
    Nervous System Trauma
    Vasoconstriction
    Vascular Smooth Muscle
    Vasodilation
    Acetylcholine
    Endothelium
    Nitric Oxide
    Endothelial Cells

    Keywords

    • cerebral vascular reactivity
    • cardiopulmonary bypass
    • rats
    • thoracic surgery

    Cite this

    Modine, T. ; Azzaoui, R. ; Ouk, T. ; Fayad, G. ; Lacroix, D. ; Warembourg, H. ; Bordet, R. ; Gourlay, T. / Changes in cerebal vascular reactivity occur early during cardiopulmonary bypass in the rat. In: Annals of Thoracic Surgery. 2006 ; Vol. 82. pp. 672-678.
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    abstract = "Cardiopulmonary bypass (CPB) is known to cause cerebrovascular dysfunction. The etiology of these complications is complex, but disruption of normal cerebral endothelial function as a consequence of inflammatory or hypoperfusion phenomena have been implicated. The aim of this study was to investigate the effect of CPB time on cerebrovascular reactivity and to investigate the correlation of these findings with measured inflammatory markers. Cerebrovascular impairment appears early after the onset of CPB. The specific loss of acetylcholine-induced vasodilation suggests endothelial cell dysfunction rather than impaired vascular smooth muscle response to nitric oxide. This loss of endothelium-dependent regulatory factors after CPB may enhance vasoconstriction, impair cerebrovascular function, and contribute to neurologic injury after CPB.",
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    Changes in cerebal vascular reactivity occur early during cardiopulmonary bypass in the rat. / Modine, T.; Azzaoui, R.; Ouk, T.; Fayad, G.; Lacroix, D.; Warembourg, H.; Bordet, R.; Gourlay, T.

    In: Annals of Thoracic Surgery, Vol. 82, 2006, p. 672-678.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Changes in cerebal vascular reactivity occur early during cardiopulmonary bypass in the rat

    AU - Modine, T.

    AU - Azzaoui, R.

    AU - Ouk, T.

    AU - Fayad, G.

    AU - Lacroix, D.

    AU - Warembourg, H.

    AU - Bordet, R.

    AU - Gourlay, T.

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    AB - Cardiopulmonary bypass (CPB) is known to cause cerebrovascular dysfunction. The etiology of these complications is complex, but disruption of normal cerebral endothelial function as a consequence of inflammatory or hypoperfusion phenomena have been implicated. The aim of this study was to investigate the effect of CPB time on cerebrovascular reactivity and to investigate the correlation of these findings with measured inflammatory markers. Cerebrovascular impairment appears early after the onset of CPB. The specific loss of acetylcholine-induced vasodilation suggests endothelial cell dysfunction rather than impaired vascular smooth muscle response to nitric oxide. This loss of endothelium-dependent regulatory factors after CPB may enhance vasoconstriction, impair cerebrovascular function, and contribute to neurologic injury after CPB.

    KW - cerebral vascular reactivity

    KW - cardiopulmonary bypass

    KW - rats

    KW - thoracic surgery

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