C–H functionalization for hydrogen isotope exchange

Jens Atzrodt, Volker Derdau, William J. Kerr, Marc Reid

Research output: Contribution to journalLiterature review

70 Citations (Scopus)
18 Downloads (Pure)

Abstract

The varied applications of hydrogen isotopes (deuterium, D, and tritium, T) in the physical and life sciences demands a range of methods for their installation in an array of molecular architectures. In this review, we describe recent advances in synthetic C–H functionalization for hydrogen isotope exchange.
Original languageEnglish
Pages (from-to)1-27
Number of pages27
JournalAngewandte Chemie International Edition
Early online date12 Oct 2017
DOIs
Publication statusE-pub ahead of print - 12 Oct 2017

Fingerprint

Isotopes
Hydrogen
Tritium
Deuterium

Keywords

  • C–H functionalization
  • hydrogen isotope exchange
  • catalysis
  • drug discovery

Cite this

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abstract = "The varied applications of hydrogen isotopes (deuterium, D, and tritium, T) in the physical and life sciences demands a range of methods for their installation in an array of molecular architectures. In this review, we describe recent advances in synthetic C–H functionalization for hydrogen isotope exchange.",
keywords = "C–H functionalization , hydrogen isotope exchange , catalysis, drug discovery",
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C–H functionalization for hydrogen isotope exchange. / Atzrodt, Jens; Derdau, Volker; Kerr, William J.; Reid, Marc.

In: Angewandte Chemie International Edition, 12.10.2017, p. 1-27.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - C–H functionalization for hydrogen isotope exchange

AU - Atzrodt, Jens

AU - Derdau, Volker

AU - Kerr, William J.

AU - Reid, Marc

N1 - This is the peer reviewed version of the following article: Atzrodt, J, Derdau, V, Kerr, WJ & Reid, M 2017, 'C–H functionalization for hydrogen isotope exchange' Angewandte Chemie International Edition, pp. 1-27, which has been published in final form at https://doi.org/10.1002/anie.201708903. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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N2 - The varied applications of hydrogen isotopes (deuterium, D, and tritium, T) in the physical and life sciences demands a range of methods for their installation in an array of molecular architectures. In this review, we describe recent advances in synthetic C–H functionalization for hydrogen isotope exchange.

AB - The varied applications of hydrogen isotopes (deuterium, D, and tritium, T) in the physical and life sciences demands a range of methods for their installation in an array of molecular architectures. In this review, we describe recent advances in synthetic C–H functionalization for hydrogen isotope exchange.

KW - C–H functionalization

KW - hydrogen isotope exchange

KW - catalysis

KW - drug discovery

UR - http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-3773

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DO - 10.1002/anie.201708903

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JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

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