Cerebral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression

Neil Dawson, Linda Ferrington, Klaus-Peter Lesch, Paul A.T Kelly

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Variation in the human serotonin transporter gene (hSERT; 5-HTT) resulting in a life-long alteration in SERT function influences anxiety and the risk of developing affective disorders. The mechanisms underlying the influence of the hSERT gene on these phenotypes remain unclear but may involve altered 5-HT receptor function. Here we characterise the cerebral metabolic response to 5-HT2A/C receptor activation in two transgenic mouse models of altered SERT function, SERT knock-out (SERT KO) and hSERT over-expressing (hSERT OE) mice, to test the hypothesis that genetically mediated variability in SERT expression alters 5-HT2A/C function. We found that a constitutive increase in SERT expression (hSERT OE) enhanced, whereas a constitutive decrease in SERT expression (SERT KO) attenuated, 5-HT2A/C function. Therefore, altered 5-HT2A/C receptor functioning in response to hSERT gene variation may contribute to its influence on affective phenotypes.
LanguageEnglish
Pages117-128
Number of pages12
JournalEuropean Neuropsychopharmacology
Volume21
Issue number1
Early online date17 Oct 2010
DOIs
Publication statusPublished - 2011

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Receptor, Serotonin, 5-HT2A
Serotonin Plasma Membrane Transport Proteins
Genes
Phenotype
Serotonin Receptors
Mood Disorders
Transgenic Mice
Anxiety

Keywords

  • serotonin transporter
  • human serotonin transporter gene
  • phenotypes

Cite this

Dawson, Neil ; Ferrington, Linda ; Lesch, Klaus-Peter ; Kelly, Paul A.T. / Cerebral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression. In: European Neuropsychopharmacology. 2011 ; Vol. 21, No. 1. pp. 117-128.
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Cerebral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression. / Dawson, Neil; Ferrington, Linda; Lesch, Klaus-Peter; Kelly, Paul A.T.

In: European Neuropsychopharmacology, Vol. 21, No. 1, 2011, p. 117-128.

Research output: Contribution to journalArticle

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