Abstract
| Original language | English |
|---|---|
| Pages (from-to) | o650-o652 |
| Journal | Acta Crystallographica Section C: Crystal Structure Communications |
| Volume | 59 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 22 Oct 2003 |
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Keywords
- antibiotic cephalexin
- isomorphic solvates
- hydration
- humidities
- crystallographic
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Cephalexin: a channel hydrate. / Kennedy, A.R.; Okoth, M.O.; Sheen, D.B.; Sherwood, J.N.; Teat, S.J.; Vrcelj, R.M.
In: Acta Crystallographica Section C: Crystal Structure Communications, Vol. 59, No. 11, 22.10.2003, p. o650-o652.Research output: Contribution to journal › Article
TY - JOUR
T1 - Cephalexin: a channel hydrate
AU - Kennedy, A.R.
AU - Okoth, M.O.
AU - Sheen, D.B.
AU - Sherwood, J.N.
AU - Teat, S.J.
AU - Vrcelj, R.M.
PY - 2003/10/22
Y1 - 2003/10/22
N2 - The antibiotic cephalexin [systematic name: d-7-(2-amino-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid] forms a range of isomorphic solvates, with the maximum hydration state of two water molecules formed only at high relative humidities. The water content of the structure reported here (C16H17N3O4S·1.9H2O) falls just short of this configuration, having three independent cephalexin molecules, one of which is disordered, and 5.72 observed water molecules in the asymmetric unit. The facile nature of the cephalexin solvation/desolvation process is found to be facilitated by a complex channel structure, which allows free movement of solvent in the crystallographic a and b directions.
AB - The antibiotic cephalexin [systematic name: d-7-(2-amino-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid] forms a range of isomorphic solvates, with the maximum hydration state of two water molecules formed only at high relative humidities. The water content of the structure reported here (C16H17N3O4S·1.9H2O) falls just short of this configuration, having three independent cephalexin molecules, one of which is disordered, and 5.72 observed water molecules in the asymmetric unit. The facile nature of the cephalexin solvation/desolvation process is found to be facilitated by a complex channel structure, which allows free movement of solvent in the crystallographic a and b directions.
KW - antibiotic cephalexin
KW - isomorphic solvates
KW - hydration
KW - humidities
KW - crystallographic
UR - http://www.blackwell-synergy.com/doi/full/10.1107/S0108270103022649
UR - http://dx.doi.org/10.1107/S0108270103022649
U2 - 10.1107/S0108270103022649
DO - 10.1107/S0108270103022649
M3 - Article
VL - 59
SP - o650-o652
JO - Acta Crystallographica Section C: Crystal Structure Communications
JF - Acta Crystallographica Section C: Crystal Structure Communications
SN - 0108-2701
IS - 11
ER -