Cephalexin: a channel hydrate

A.R. Kennedy, M.O. Okoth, D.B. Sheen, J.N. Sherwood, S.J. Teat, R.M. Vrcelj

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The antibiotic cephalexin [systematic name: d-7-(2-amino-2-phenyl­acet­amido)-3-methyl-8-oxo-5-thia-1-aza­bi­cyclo­[4.2.0]oct-2-ene-2-carboxyl­ic acid] forms a range of isomorphic solvates, with the maximum hydration state of two water mol­ecules formed only at high relative humidities. The water content of the structure reported here (C16H17N3O4S·1.9H2O) falls just short of this configuration, having three independent cephalexin mol­ecules, one of which is disordered, and 5.72 observed water mol­ecules in the asymmetric unit. The facile nature of the cephalexin solvation/desolvation process is found to be facilitated by a complex channel structure, which allows free movement of solvent in the crystallographic a and b directions.
Original languageEnglish
Pages (from-to)o650-o652
JournalActa Crystallographica Section C: Crystal Structure Communications
Volume59
Issue number11
DOIs
Publication statusPublished - 22 Oct 2003

Fingerprint

Cephalexin
Hydrates
Molecules
Water
Solvation
Carboxylic Acids
Humidity
Hydration
Water content
Names
Atmospheric humidity
Anti-Bacterial Agents

Keywords

  • antibiotic cephalexin
  • isomorphic solvates
  • hydration
  • humidities
  • crystallographic

Cite this

Kennedy, A.R. ; Okoth, M.O. ; Sheen, D.B. ; Sherwood, J.N. ; Teat, S.J. ; Vrcelj, R.M. / Cephalexin: a channel hydrate. In: Acta Crystallographica Section C: Crystal Structure Communications. 2003 ; Vol. 59, No. 11. pp. o650-o652.
@article{4d54eb3b727e4548818565d850b13216,
title = "Cephalexin: a channel hydrate",
abstract = "The antibiotic cephalexin [systematic name: d-7-(2-amino-2-phenyl­acet­amido)-3-methyl-8-oxo-5-thia-1-aza­bi­cyclo­[4.2.0]oct-2-ene-2-carboxyl­ic acid] forms a range of isomorphic solvates, with the maximum hydration state of two water mol­ecules formed only at high relative humidities. The water content of the structure reported here (C16H17N3O4S·1.9H2O) falls just short of this configuration, having three independent cephalexin mol­ecules, one of which is disordered, and 5.72 observed water mol­ecules in the asymmetric unit. The facile nature of the cephalexin solvation/desolvation process is found to be facilitated by a complex channel structure, which allows free movement of solvent in the crystallographic a and b directions.",
keywords = "antibiotic cephalexin, isomorphic solvates, hydration, humidities, crystallographic",
author = "A.R. Kennedy and M.O. Okoth and D.B. Sheen and J.N. Sherwood and S.J. Teat and R.M. Vrcelj",
year = "2003",
month = "10",
day = "22",
doi = "10.1107/S0108270103022649",
language = "English",
volume = "59",
pages = "o650--o652",
journal = "Acta Crystallographica Section C: Crystal Structure Communications",
issn = "0108-2701",
number = "11",

}

Cephalexin: a channel hydrate. / Kennedy, A.R.; Okoth, M.O.; Sheen, D.B.; Sherwood, J.N.; Teat, S.J.; Vrcelj, R.M.

In: Acta Crystallographica Section C: Crystal Structure Communications, Vol. 59, No. 11, 22.10.2003, p. o650-o652.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cephalexin: a channel hydrate

AU - Kennedy, A.R.

AU - Okoth, M.O.

AU - Sheen, D.B.

AU - Sherwood, J.N.

AU - Teat, S.J.

AU - Vrcelj, R.M.

PY - 2003/10/22

Y1 - 2003/10/22

N2 - The antibiotic cephalexin [systematic name: d-7-(2-amino-2-phenyl­acet­amido)-3-methyl-8-oxo-5-thia-1-aza­bi­cyclo­[4.2.0]oct-2-ene-2-carboxyl­ic acid] forms a range of isomorphic solvates, with the maximum hydration state of two water mol­ecules formed only at high relative humidities. The water content of the structure reported here (C16H17N3O4S·1.9H2O) falls just short of this configuration, having three independent cephalexin mol­ecules, one of which is disordered, and 5.72 observed water mol­ecules in the asymmetric unit. The facile nature of the cephalexin solvation/desolvation process is found to be facilitated by a complex channel structure, which allows free movement of solvent in the crystallographic a and b directions.

AB - The antibiotic cephalexin [systematic name: d-7-(2-amino-2-phenyl­acet­amido)-3-methyl-8-oxo-5-thia-1-aza­bi­cyclo­[4.2.0]oct-2-ene-2-carboxyl­ic acid] forms a range of isomorphic solvates, with the maximum hydration state of two water mol­ecules formed only at high relative humidities. The water content of the structure reported here (C16H17N3O4S·1.9H2O) falls just short of this configuration, having three independent cephalexin mol­ecules, one of which is disordered, and 5.72 observed water mol­ecules in the asymmetric unit. The facile nature of the cephalexin solvation/desolvation process is found to be facilitated by a complex channel structure, which allows free movement of solvent in the crystallographic a and b directions.

KW - antibiotic cephalexin

KW - isomorphic solvates

KW - hydration

KW - humidities

KW - crystallographic

UR - http://www.blackwell-synergy.com/doi/full/10.1107/S0108270103022649

UR - http://dx.doi.org/10.1107/S0108270103022649

U2 - 10.1107/S0108270103022649

DO - 10.1107/S0108270103022649

M3 - Article

VL - 59

SP - o650-o652

JO - Acta Crystallographica Section C: Crystal Structure Communications

JF - Acta Crystallographica Section C: Crystal Structure Communications

SN - 0108-2701

IS - 11

ER -