Cephalexin: a channel hydrate

A.R. Kennedy, M.O. Okoth, D.B. Sheen, J.N. Sherwood, S.J. Teat, R.M. Vrcelj

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


The antibiotic cephalexin [systematic name: d-7-(2-amino-2-phenyl­acet­amido)-3-methyl-8-oxo-5-thia-1-aza­bi­cyclo­[4.2.0]oct-2-ene-2-carboxyl­ic acid] forms a range of isomorphic solvates, with the maximum hydration state of two water mol­ecules formed only at high relative humidities. The water content of the structure reported here (C16H17N3O4S·1.9H2O) falls just short of this configuration, having three independent cephalexin mol­ecules, one of which is disordered, and 5.72 observed water mol­ecules in the asymmetric unit. The facile nature of the cephalexin solvation/desolvation process is found to be facilitated by a complex channel structure, which allows free movement of solvent in the crystallographic a and b directions.
Original languageEnglish
Pages (from-to)o650-o652
JournalActa Crystallographica Section C: Crystal Structure Communications
Issue number11
Publication statusPublished - 22 Oct 2003


  • antibiotic cephalexin
  • isomorphic solvates
  • hydration
  • humidities
  • crystallographic


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