Cellular bases for human atrial fibrillation

Antony J. Workman, Kathleen A. Kane, Andrew C. Rankin

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Abstract

Atrial fibrillation (AF) causes substantial morbidity and mortality. It may be triggered and sustained by either reentrant or nonreentrant electrical activity. Human atrial cellular refractory period is shortened in chronic AF, likely aiding reentry. The ionic and molecular mechanisms are not fully understood and may include increased inward rectifier K+ current and altered Ca2+ handling. Heart failure, a major cause of AF, may involve arrhythmogenic atrial electrical remodeling, but the pattern is unclear in humans. Beta-blocker therapy prolongs atrial cell refractory period; a potentially antiarrhythmic influence, but the ionic and molecular mechanisms are unclear. The search for drugs to suppress AF without causing ventricular arrhythmias has been aided by basic studies of cellular mechanisms of AF. It remains to be seen whether such drugs will improve patient treatment.
Original languageEnglish
Pages (from-to)S1-S6
JournalHeart Rhythm
Volume5
Issue number6
Early online date17 Jan 2008
DOIs
Publication statusPublished - 30 Jun 2008

Keywords

  • arrhythmias
  • atrial fibrillation
  • beta-blocker
  • electrical remodeling
  • heart failure
  • ion current
  • refractory period
  • transmembrane action potential
  • pharmacology

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