Cell spreading correlates with calculated logP of amino acid-modified surfaces

Rachel E. Rawsterne, Simon J. Todd, Julie E. Gough, David Farrar, Frank J. M. Rutten, Morgan R. Alexander, Rein V. Ulijn

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The interactions of cells with synthetic surfaces are a critical factor in biomaterials design and it would be invaluable if these interactions could be precisely controlled and predicted. Hydrophobicity or lipophilicity of the surface is commonly used to rationalize cell attachment to materials. In the pharmaceutical sciences it is common practice to use logP, the partitioning coefficient between water and octanol, as a reliable indicator of the hydrophobicity or lipophilicity of (drug) molecules. A number of methods are available to reliably predict logP values directly from molecular structure. In this paper we demonstrate that logP values calculated on the basis of the molecular structure of a range of surface-tethered groups correlate well with cell spreading. To our knowledge this is the first method to predict cell spreading on chemically modified surfaces via nonspecific interactions. (c) 2007 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

LanguageEnglish
Pages715-721
Number of pages7
JournalActa Biomaterialia
Volume3
Issue number5
DOIs
Publication statusPublished - Sep 2007

Fingerprint

Amino acids
Molecular Structure
Hydrophobic and Hydrophilic Interactions
Amino Acids
Hydrophobicity
Molecular structure
Artificial Cells
Octanols
Biocompatible Materials
Cell Communication
Pharmaceutical Preparations
Biomaterials
Drug products
Water
Molecules

Keywords

  • cell spreading
  • calculated logP
  • amino acid-modified surfaces
  • surface functionalization
  • osteoblast

Cite this

Rawsterne, R. E., Todd, S. J., Gough, J. E., Farrar, D., Rutten, F. J. M., Alexander, M. R., & Ulijn, R. V. (2007). Cell spreading correlates with calculated logP of amino acid-modified surfaces. Acta Biomaterialia, 3(5), 715-721. https://doi.org/10.1016/j.actbio.2007.02.006
Rawsterne, Rachel E. ; Todd, Simon J. ; Gough, Julie E. ; Farrar, David ; Rutten, Frank J. M. ; Alexander, Morgan R. ; Ulijn, Rein V. / Cell spreading correlates with calculated logP of amino acid-modified surfaces. In: Acta Biomaterialia. 2007 ; Vol. 3, No. 5. pp. 715-721.
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Rawsterne, RE, Todd, SJ, Gough, JE, Farrar, D, Rutten, FJM, Alexander, MR & Ulijn, RV 2007, 'Cell spreading correlates with calculated logP of amino acid-modified surfaces' Acta Biomaterialia, vol. 3, no. 5, pp. 715-721. https://doi.org/10.1016/j.actbio.2007.02.006

Cell spreading correlates with calculated logP of amino acid-modified surfaces. / Rawsterne, Rachel E.; Todd, Simon J.; Gough, Julie E.; Farrar, David; Rutten, Frank J. M.; Alexander, Morgan R.; Ulijn, Rein V.

In: Acta Biomaterialia, Vol. 3, No. 5, 09.2007, p. 715-721.

Research output: Contribution to journalArticle

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Rawsterne RE, Todd SJ, Gough JE, Farrar D, Rutten FJM, Alexander MR et al. Cell spreading correlates with calculated logP of amino acid-modified surfaces. Acta Biomaterialia. 2007 Sep;3(5):715-721. https://doi.org/10.1016/j.actbio.2007.02.006