Cell death in parasitic protozoa: regulated or incidental?

William R Proto, Graham Coombs, Jeremy Mottram

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Apoptosis and other types of regulated cell death have been defined as fundamental processes in plant and animal development, but the occurrence of, and possible roles for, regulated cell death in parasitic protozoa remain controversial. A key problem has been the difficulty in reconciling the presence of apparent morphological markers of apoptosis and the notable absence of some of the key executioners functioning in higher eukaryotes. Here, we review the evidence for regulated cell death pathways in selected parasitic protozoa and propose that cell death in these organisms be classified into just two primary types: necrosis and incidental death. It is our opinion that dedicated molecular machinery required for the initiation and execution of regulated cell death has yet to be convincingly identified.
Original languageEnglish
Pages (from-to)58-66
Number of pages9
JournalNature Reviews Microbiology
Volume11
DOIs
Publication statusPublished - Jan 2013

Keywords

  • cell death
  • parasitic protozoa
  • apoptosis
  • cell life cycle

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