Abstract
| Language | English |
|---|---|
| Pages | 12944-12950 |
| Number of pages | 7 |
| Journal | Analytical Chemistry |
| Volume | 90 |
| Issue number | 21 |
| Early online date | 3 Oct 2018 |
| DOIs | |
| Publication status | Published - 6 Nov 2018 |
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Keywords
- electrochemical sensors
- near infrared quantum dots
- whole blood
Cite this
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Cathodic quantum dot facilitated electrochemiluminescent detection. / Stewart, Alasdair J.; Brown, Kelly; Dennany, Lynn.
In: Analytical Chemistry, Vol. 90, No. 21, 06.11.2018, p. 12944-12950.Research output: Contribution to journal › Article
TY - JOUR
T1 - Cathodic quantum dot facilitated electrochemiluminescent detection
AU - Stewart, Alasdair J.
AU - Brown, Kelly
AU - Dennany, Lynn
N1 - This document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in Analytical Chemistry, copyright © American Chemical Society after peer review.
PY - 2018/11/6
Y1 - 2018/11/6
N2 - The expansion of electrochemical sensors to biomedical applications at point of care requires these sensors to undergo analysis without any pre-treatment of extraction. This poses a major challenge for all electrochemical sensors including electrochemiluminescent (ECL) based sensors. ECL offers many advantages for biomedical applications however; obtaining results from complex matrices has proven to be a large hurdle for the application of ECL sensors within this field. This work demonstrates the potential of cathodic ECL to detect and quantify homocysteine with 0.1 nM limit of detection, which is associated with hyperhomocysteinemia, in blood. This near infrared quantum dot (NIR QD) based ECL sensor displays good linearity allowing for rapid detection and providing a basis for exploitation of ECL based sensors for biomedical diagnostics utilising homocysteine as a model cathodic co-reactant. This work will lay the foundations for future developments in biosensing and imaging fields and stands as an initial proof of concept for the utilization of cathodic ECL technologies for biomedical applications once the limits of detection within clinically relevant levels has been achieved. This work illustrates the potential of cathodic ECL sensors, using Hcy as a model complex, for the detection of biomolecules.
AB - The expansion of electrochemical sensors to biomedical applications at point of care requires these sensors to undergo analysis without any pre-treatment of extraction. This poses a major challenge for all electrochemical sensors including electrochemiluminescent (ECL) based sensors. ECL offers many advantages for biomedical applications however; obtaining results from complex matrices has proven to be a large hurdle for the application of ECL sensors within this field. This work demonstrates the potential of cathodic ECL to detect and quantify homocysteine with 0.1 nM limit of detection, which is associated with hyperhomocysteinemia, in blood. This near infrared quantum dot (NIR QD) based ECL sensor displays good linearity allowing for rapid detection and providing a basis for exploitation of ECL based sensors for biomedical diagnostics utilising homocysteine as a model cathodic co-reactant. This work will lay the foundations for future developments in biosensing and imaging fields and stands as an initial proof of concept for the utilization of cathodic ECL technologies for biomedical applications once the limits of detection within clinically relevant levels has been achieved. This work illustrates the potential of cathodic ECL sensors, using Hcy as a model complex, for the detection of biomolecules.
KW - electrochemical sensors
KW - near infrared quantum dots
KW - whole blood
U2 - 10.1021/acs.analchem.8b03572
DO - 10.1021/acs.analchem.8b03572
M3 - Article
VL - 90
SP - 12944
EP - 12950
JO - Analytical Chemistry
T2 - Analytical Chemistry
JF - Analytical Chemistry
SN - 0003-2700
IS - 21
ER -