Catalytic reductive N-alkylation of amines using carboxylic acids

Keith G.  Andrews; Declan M.  Summers; Liam J. Donnelly; Ross M.  Denton

doi:10.1039/c5cc08881j

Catalytic reductive N-alkylation of amines using carboxylic acids

Keith G. Andrews, Declan M. Summers, Liam J. Donnelly, Ross M. Denton

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

12 Downloads (Pure)

Abstract

We report a catalytic reductive alkylation reaction of primary or secondary amines with carboxylic acids. The two-phase process involves silane mediated direct amidation followed by catalytic reduction.

Original language	English
Pages (from-to)	1855-1858
Number of pages	4
Journal	Chemical Communications
Volume	2016
Issue number	9
Early online date	3 Dec 2015
DOIs	https://doi.org/10.1039/c5cc08881j
Publication status	Published - 1 Jan 2016

Keywords

amines
carboxylic acids
catalytic reductive N-alkylation
aldehydes

Access to Document

10.1039/c5cc08881j

Andrews-etal-CC2016-Catalytic-reductive-N-alkylation-amines-carboxylic-acidsAccepted author manuscript, 796 KB

Cite this

@article{733aa79a55704fdbb4afb4af00d4e40c,

title = "Catalytic reductive N-alkylation of amines using carboxylic acids",

abstract = "We report a catalytic reductive alkylation reaction of primary or secondary amines with carboxylic acids. The two-phase process involves silane mediated direct amidation followed by catalytic reduction.",

keywords = "amines, carboxylic acids, catalytic reductive N-alkylation, aldehydes",

author = "Andrews, {Keith G.} and Summers, {Declan M.} and Donnelly, {Liam J.} and Denton, {Ross M.}",

note = "Chem. Commun., 2016,52, 1855-1858",

year = "2016",

month = jan,

day = "1",

doi = "10.1039/c5cc08881j",

language = "English",

volume = "2016",

pages = "1855--1858",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "9",

}

TY - JOUR

T1 - Catalytic reductive N-alkylation of amines using carboxylic acids

AU - Andrews, Keith G.

AU - Summers, Declan M.

AU - Donnelly, Liam J.

AU - Denton, Ross M.

N1 - Chem. Commun., 2016,52, 1855-1858

PY - 2016/1/1

Y1 - 2016/1/1

N2 - We report a catalytic reductive alkylation reaction of primary or secondary amines with carboxylic acids. The two-phase process involves silane mediated direct amidation followed by catalytic reduction.

AB - We report a catalytic reductive alkylation reaction of primary or secondary amines with carboxylic acids. The two-phase process involves silane mediated direct amidation followed by catalytic reduction.

KW - amines

KW - carboxylic acids

KW - catalytic reductive N-alkylation

KW - aldehydes

U2 - 10.1039/c5cc08881j

DO - 10.1039/c5cc08881j

M3 - Article

SN - 1359-7345

VL - 2016

SP - 1855

EP - 1858

JO - Chemical Communications

JF - Chemical Communications

IS - 9

ER -

Catalytic reductive N-alkylation of amines using carboxylic acids

Abstract

Keywords

Access to Document

Fingerprint

Cite this