Abstract
| Language | English |
|---|---|
| Pages | 337-339 |
| Number of pages | 3 |
| Journal | Organic Letters |
| Volume | 5 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 6 Feb 2003 |
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Keywords
- catalytic sysnthesis
- Stille coupling
- orthogonal conditions
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Catalytic asymmetric synthesis of a 1-deoxy-1,1-difluoro-D-xylulose. / Cox, Liam R; DeBoos, Gareth A; Fullbrook, Jeremy J; Percy, Jonathan; Spencer, Neil S; Tolley, Malcolm.
In: Organic Letters, Vol. 5, No. 3, 06.02.2003, p. 337-339 .Research output: Contribution to journal › Article
TY - JOUR
T1 - Catalytic asymmetric synthesis of a 1-deoxy-1,1-difluoro-D-xylulose
AU - Cox, Liam R
AU - DeBoos, Gareth A
AU - Fullbrook, Jeremy J
AU - Percy, Jonathan
AU - Spencer, Neil S
AU - Tolley, Malcolm
PY - 2003/2/6
Y1 - 2003/2/6
N2 - A new route, of potential strategic importance, to a difluorosugar analogue has been developed. Key steps included a Stille coupling and a highly regio- and enantioselective dihydroxylation of a highly substituted diene. Protecting groups were chosen to enhance the reactivity of the disubstituted allylic fragment in the AD reaction and allow deprotection under orthogonal conditions.
AB - A new route, of potential strategic importance, to a difluorosugar analogue has been developed. Key steps included a Stille coupling and a highly regio- and enantioselective dihydroxylation of a highly substituted diene. Protecting groups were chosen to enhance the reactivity of the disubstituted allylic fragment in the AD reaction and allow deprotection under orthogonal conditions.
KW - catalytic sysnthesis
KW - Stille coupling
KW - orthogonal conditions
U2 - 10.1021/ol02735
DO - 10.1021/ol02735
M3 - Article
VL - 5
SP - 337
EP - 339
JO - Organic Letters
T2 - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 3
ER -