Catalytic antibodies: a new window on protein chemistry

Colin J. Suckling, Catriona M. Tedford, George R. Proctor, Abedawn I. Khalaf, Laura M. Bence, William H. Stimson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A review with 10 refs. Catalytic antibodies have created a new dimension in protein chem. In these studies it is particularly valuable to investigate systems for which natural enzymic catalysts are unknown. Several ways of prepg. homochiral building blocks for org. synthesis have been examd. by the authors. Antibodies that catalyze the Diels-Alder reaction have been characterized. The target reaction was the addn. of acetoxybutadiene to N-substituted maleimides, a reaction that should give a pentafunctional homochiral building block. Catalytic antibodies can give insight into the mechanism of catalysis by proteins. An adventitious hydrolytic antibody that cleaves activated esters was investigated. An antibody raised to ampicillin for anal. purposes has also been shown to catalyze hydrolysis of the β-lactam ring.
Original languageEnglish
Pages (from-to)201-210
Number of pages10
JournalCiba Foundation Symposium
Volume159
Issue numberCatal. Antibodies
DOIs
Publication statusPublished - 1991

Fingerprint

Catalytic Antibodies
Antibodies
Maleimides
Lactams
Proteins
Ampicillin
Catalysis
Hydrolysis
Esters
Catalysts

Keywords

  • protein chemistry
  • catalytic antibodies
  • n-substituted maleimides

Cite this

Suckling, C. J., Tedford, C. M., Proctor, G. R., Khalaf, A. I., Bence, L. M., & Stimson, W. H. (1991). Catalytic antibodies: a new window on protein chemistry. Ciba Foundation Symposium, 159(Catal. Antibodies), 201-210. https://doi.org/10.1002/9780470514108.ch14
Suckling, Colin J. ; Tedford, Catriona M. ; Proctor, George R. ; Khalaf, Abedawn I. ; Bence, Laura M. ; Stimson, William H. / Catalytic antibodies: a new window on protein chemistry. In: Ciba Foundation Symposium. 1991 ; Vol. 159, No. Catal. Antibodies. pp. 201-210.
@article{3efe44160d224c089e668ce65c846728,
title = "Catalytic antibodies: a new window on protein chemistry",
abstract = "A review with 10 refs. Catalytic antibodies have created a new dimension in protein chem. In these studies it is particularly valuable to investigate systems for which natural enzymic catalysts are unknown. Several ways of prepg. homochiral building blocks for org. synthesis have been examd. by the authors. Antibodies that catalyze the Diels-Alder reaction have been characterized. The target reaction was the addn. of acetoxybutadiene to N-substituted maleimides, a reaction that should give a pentafunctional homochiral building block. Catalytic antibodies can give insight into the mechanism of catalysis by proteins. An adventitious hydrolytic antibody that cleaves activated esters was investigated. An antibody raised to ampicillin for anal. purposes has also been shown to catalyze hydrolysis of the β-lactam ring.",
keywords = "protein chemistry , catalytic antibodies, n-substituted maleimides",
author = "Suckling, {Colin J.} and Tedford, {Catriona M.} and Proctor, {George R.} and Khalaf, {Abedawn I.} and Bence, {Laura M.} and Stimson, {William H.}",
year = "1991",
doi = "10.1002/9780470514108.ch14",
language = "English",
volume = "159",
pages = "201--210",
journal = "Ciba Foundation Symposium",
issn = "0300-5208",
publisher = "Wiley Subscription Services",
number = "Catal. Antibodies",

}

Suckling, CJ, Tedford, CM, Proctor, GR, Khalaf, AI, Bence, LM & Stimson, WH 1991, 'Catalytic antibodies: a new window on protein chemistry', Ciba Foundation Symposium, vol. 159, no. Catal. Antibodies, pp. 201-210. https://doi.org/10.1002/9780470514108.ch14

Catalytic antibodies: a new window on protein chemistry. / Suckling, Colin J.; Tedford, Catriona M.; Proctor, George R.; Khalaf, Abedawn I.; Bence, Laura M.; Stimson, William H.

In: Ciba Foundation Symposium, Vol. 159, No. Catal. Antibodies, 1991, p. 201-210.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Catalytic antibodies: a new window on protein chemistry

AU - Suckling, Colin J.

AU - Tedford, Catriona M.

AU - Proctor, George R.

AU - Khalaf, Abedawn I.

AU - Bence, Laura M.

AU - Stimson, William H.

PY - 1991

Y1 - 1991

N2 - A review with 10 refs. Catalytic antibodies have created a new dimension in protein chem. In these studies it is particularly valuable to investigate systems for which natural enzymic catalysts are unknown. Several ways of prepg. homochiral building blocks for org. synthesis have been examd. by the authors. Antibodies that catalyze the Diels-Alder reaction have been characterized. The target reaction was the addn. of acetoxybutadiene to N-substituted maleimides, a reaction that should give a pentafunctional homochiral building block. Catalytic antibodies can give insight into the mechanism of catalysis by proteins. An adventitious hydrolytic antibody that cleaves activated esters was investigated. An antibody raised to ampicillin for anal. purposes has also been shown to catalyze hydrolysis of the β-lactam ring.

AB - A review with 10 refs. Catalytic antibodies have created a new dimension in protein chem. In these studies it is particularly valuable to investigate systems for which natural enzymic catalysts are unknown. Several ways of prepg. homochiral building blocks for org. synthesis have been examd. by the authors. Antibodies that catalyze the Diels-Alder reaction have been characterized. The target reaction was the addn. of acetoxybutadiene to N-substituted maleimides, a reaction that should give a pentafunctional homochiral building block. Catalytic antibodies can give insight into the mechanism of catalysis by proteins. An adventitious hydrolytic antibody that cleaves activated esters was investigated. An antibody raised to ampicillin for anal. purposes has also been shown to catalyze hydrolysis of the β-lactam ring.

KW - protein chemistry

KW - catalytic antibodies

KW - n-substituted maleimides

U2 - 10.1002/9780470514108.ch14

DO - 10.1002/9780470514108.ch14

M3 - Article

VL - 159

SP - 201

EP - 210

JO - Ciba Foundation Symposium

JF - Ciba Foundation Symposium

SN - 0300-5208

IS - Catal. Antibodies

ER -