Catalytic antibodies: a new window on protein chemistry

Colin J. Suckling, Catriona M. Tedford, George R. Proctor, Abedawn I. Khalaf, Laura M. Bence, William H. Stimson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A review with 10 refs. Catalytic antibodies have created a new dimension in protein chem. In these studies it is particularly valuable to investigate systems for which natural enzymic catalysts are unknown. Several ways of prepg. homochiral building blocks for org. synthesis have been examd. by the authors. Antibodies that catalyze the Diels-Alder reaction have been characterized. The target reaction was the addn. of acetoxybutadiene to N-substituted maleimides, a reaction that should give a pentafunctional homochiral building block. Catalytic antibodies can give insight into the mechanism of catalysis by proteins. An adventitious hydrolytic antibody that cleaves activated esters was investigated. An antibody raised to ampicillin for anal. purposes has also been shown to catalyze hydrolysis of the β-lactam ring.
Original languageEnglish
Pages (from-to)201-210
Number of pages10
JournalCiba Foundation Symposium
Volume159
Issue numberCatal. Antibodies
DOIs
Publication statusPublished - 1991

Keywords

  • protein chemistry
  • catalytic antibodies
  • n-substituted maleimides

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