Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol

Nicola Caldwell, Craig Jamieson, Iain Simpson, Allan J B Watson

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)
43 Downloads (Pure)


A catalytic amidation method has been developed, employing 2,2,2-trifluoroethanol to facilitate condensation of unactivated esters and amines, enabling the synthesis of a range of amide products in good to excellent yields. Mechanistic studies indicate the reaction proceeds through a trifluoroethanol-derived active ester intermediate.

Original languageEnglish
Pages (from-to)9495-9498
Number of pages4
JournalChemical Communications
Issue number46
Early online date8 May 2015
Publication statusPublished - 11 Jun 2015


  • catalysis
  • trifluoroethanol
  • catalytic amidation


Dive into the research topics of 'Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol'. Together they form a unique fingerprint.

Cite this