Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol

Nicola Caldwell, Craig Jamieson, Iain Simpson, Allan J B Watson

Research output: Contribution to journalArticle

31 Citations (Scopus)
36 Downloads (Pure)

Abstract

A catalytic amidation method has been developed, employing 2,2,2-trifluoroethanol to facilitate condensation of unactivated esters and amines, enabling the synthesis of a range of amide products in good to excellent yields. Mechanistic studies indicate the reaction proceeds through a trifluoroethanol-derived active ester intermediate.

Original languageEnglish
Pages (from-to)9495-9498
Number of pages4
JournalChemical Communications
Volume51
Issue number46
Early online date8 May 2015
DOIs
Publication statusPublished - 11 Jun 2015

Fingerprint

Trifluoroethanol
Esters
Derivatives
Amides
Amines
Condensation

Keywords

  • catalysis
  • trifluoroethanol
  • catalytic amidation

Cite this

Caldwell, Nicola ; Jamieson, Craig ; Simpson, Iain ; Watson, Allan J B. / Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol. In: Chemical Communications. 2015 ; Vol. 51, No. 46. pp. 9495-9498.
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Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol. / Caldwell, Nicola; Jamieson, Craig; Simpson, Iain; Watson, Allan J B.

In: Chemical Communications, Vol. 51, No. 46, 11.06.2015, p. 9495-9498.

Research output: Contribution to journalArticle

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