TY - JOUR
T1 - Caribbean multi-centre study of Klebsiella pneumoniae
T2 - whole-genome sequencing, antimicrobial resistance and virulence factors
AU - Heinz, Eva
AU - Brindle, Richard
AU - Morgan-McCalla, Andrina
AU - Peters, Keisha
AU - Thomson, Nicholas R.
PY - 2019/4/29
Y1 - 2019/4/29
N2 - The surveillance of antimicrobial-resistant isolates has proven to be one of the most valuable tools to understand the global rise of multidrug-resistant bacterial pathogens. We report the first insights into the current situation in the Caribbean, where a pilot project to monitor antimicrobial resistance (AMR) through phenotypic resistance measurements combined with whole-genome sequencing was set up in collaboration with the Caribbean Public Health Agency (CARPHA). Our first study focused on Klebsiella pneumoniae, a highly relevant organism amongst the Gram-negative opportunistic pathogens worldwide causing hospital- and community-acquired infections. Our results show that not only carbapenem resistance, but also hypervirulent strains, are circulating in patients in the Caribbean. Our current data does not allow us to infer their prevalence in the population. We argue for the urgent need to further support AMR surveillance and stewardship in this almost uncharted territory, which can make a significant impact on the reduction of antimicrobial usage. This article contains data hosted by Microreact (https://microreact.org).
AB - The surveillance of antimicrobial-resistant isolates has proven to be one of the most valuable tools to understand the global rise of multidrug-resistant bacterial pathogens. We report the first insights into the current situation in the Caribbean, where a pilot project to monitor antimicrobial resistance (AMR) through phenotypic resistance measurements combined with whole-genome sequencing was set up in collaboration with the Caribbean Public Health Agency (CARPHA). Our first study focused on Klebsiella pneumoniae, a highly relevant organism amongst the Gram-negative opportunistic pathogens worldwide causing hospital- and community-acquired infections. Our results show that not only carbapenem resistance, but also hypervirulent strains, are circulating in patients in the Caribbean. Our current data does not allow us to infer their prevalence in the population. We argue for the urgent need to further support AMR surveillance and stewardship in this almost uncharted territory, which can make a significant impact on the reduction of antimicrobial usage. This article contains data hosted by Microreact (https://microreact.org).
KW - antimicrobial resistance
KW - genomics
KW - Klebsiella pneumoniae
U2 - 10.1099/mgen.0.000266
DO - 10.1099/mgen.0.000266
M3 - Article
C2 - 31038449
AN - SCOPUS:85067268482
SN - 2057-5858
VL - 5
SP - 1
EP - 12
JO - Microbial Genomics
JF - Microbial Genomics
IS - 5
ER -