Carbon nanotubes for stabilization of nanostructured lipid particles

Nicholas P. Gaunt, Yogita Patil-Sen, Matthew J. Baker, Chandrashekhar V. Kulkarni

Research output: Contribution to journalArticle

11 Citations (Scopus)
56 Downloads (Pure)

Abstract

Carbon nanotubes (CNTs) are increasingly studied for innovative biotechnological applications particularly where they are combined with essential biological materials like lipids. Lipids have been used earlier for enhancing the dispersibility of CNTs in aqueous solutions. Here we report a novel application of CNTs for stabilization of internally self-assembled nanostructured lipid particles of 2-5 μm size. Single-walled (pristine) as well as -OH and -COOH functionalized multi-walled CNTs were employed to produce nanostructured emulsions which stayed stable for months and could be re-dispersed after complete dehydration. Concentrations of CNTs employed for stabilization were very low; moreover CNTs were well-decorated with lipid molecules. These features contribute towards reducing their toxicity and improving biocompatibility for biomedical and pharmaceutical applications. Our approach paves the way for future development of combination therapies employing both CNTs and nanostructured lipid self-assembly together as carriers of different drugs.

Original languageEnglish
Pages (from-to)1090-1095
Number of pages6
JournalNanoscale
Volume7
Issue number3
Early online date20 Nov 2014
DOIs
Publication statusPublished - 21 Jan 2015

Keywords

  • biocompatibility
  • biological materials
  • carbon
  • drug therapy
  • lipids
  • self assembly
  • stabilization
  • yam
  • biotechnological applications
  • combination therapy
  • dispersibilities
  • lipid particles
  • multi-walled CNTs
  • nano-structured
  • novel applications
  • pharmaceutical applications

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