Can parasitic worms cure the modern world's ills?

Margaret M. Harnett, William Harnett

Research output: Contribution to journalLiterature review

  • 2 Citations

Abstract

There has been increasing recognition that the alarming surge in allergy and autoimmunity in the industrialised and developing worlds shadows the rapid eradication of pathogens, such as parasitic helminths. Appreciation of this has fuelled an explosion in research investigating the therapeutic potential of these worms. This review considers the current state-of-play with a particular focus on exciting recent advances in the identification of potential novel targets for immunomodulation that can be exploited therapeutically. Furthermore, we contemplate the prospects for designing worm-derived immunotherapies for an ever-widening range of inflammatory diseases, including, for example, obesity, cardiovascular disease, and ageing as well as neurodevelopmental disorders like autism.
LanguageEnglish
Number of pages12
JournalTrends in Parasitology
Early online date9 Jun 2017
DOIs
StateE-pub ahead of print - 9 Jun 2017

Fingerprint

Therapeutic Human Experimentation
Immunomodulation
Explosions
Helminths
Autistic Disorder
Autoimmunity
Immunotherapy
Hypersensitivity
Cardiovascular Diseases
Obesity
Neurodevelopmental Disorders

Keywords

  • helminth
  • drug development
  • immunomodulation

Cite this

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Can parasitic worms cure the modern world's ills? / Harnett, Margaret M.; Harnett, William.

In: Trends in Parasitology, 09.06.2017.

Research output: Contribution to journalLiterature review

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