Can blood flow in the bone be measured using coloured labelled Microspheres?

H. Ghazzawi, S. Abouel-Enin, I. Reichert, T. Gourlay

    Research output: Contribution to journalArticlepeer-review


    This study was designed to determine whether coloured micro-spheres represent a realistic alternative to more conventional techniques for the assessment of bone blood flow (BBF). BBF is normally measured using radioactive labelled micro-spheres, a technique that is accurate, but becoming increasingly challenged for safety and environmental reasons. Coloured micro-spheres come in two varieties, dye-fixed and dye eluting, and both have been employed for the measurement of blood flow in soft tissue for some time. However, measuring blood flow in bone presents a different challenge to that of soft tissue, insofar as the bone has to be dissolved using harsh chemicals to enable the harvesting of the micro-spheres for counting. This study therefore was designed to determine whether these micro-spheres would survive the harvesting process, and whether they could be identified and counted afterwards.
    Original languageEnglish
    JournalInternet Journal of Laboratory Medicine
    Issue number2
    Publication statusPublished - 2009


    • microspheres
    • blood flow
    • medicine


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