Can anisotropy enhance the spatial uniformity of drug distribution in biological tissue? 

Sean McGinty, Marcus Wheel, Sean McKee, Christopher McCormick, Craig McKittrick, Simon Kennedy, Keith G. Oldroyd

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

Abstract

Local drug delivery to biological tissue is now common in clinical practice. In recent years, mathematical and computational modelling has been increasingly employed to aid in the understanding of drug delivery kinetics and drug distribution in tissue. Models typically assume isotropic properties within the tissue, which is often far from reality, and since spatially uniform drug distributions are often desired, it is often not clear what effect the anisotropy has on drug distribution. In this paper we consider drug transport in tissue which possesses anisotropic diffusion properties. We demonstrate, by considering the example of a drug-eluting stent, that the anisotropy can enhance the uniformity of drug distribution in the tissue. This may have implications on the complexity of model required.
Original languageEnglish
Title of host publication4th International Conference on Computational & Mathematical Biomedical Engineering
EditorsPerumal Nithiarasu, Elisa Budyn
Place of PublicationSwansea
Pages194-197
Number of pages4
Publication statusPublished - 1 Jul 2015
Event4th International Conference on Computational & Mathematical Biomedical Engineering - Paris, Paris, France
Duration: 29 Jun 20151 Jul 2015

Conference

Conference4th International Conference on Computational & Mathematical Biomedical Engineering
Abbreviated titleCMBE2015
CountryFrance
CityParis
Period29/06/151/07/15

Fingerprint

Anisotropy
Tissue
Drug delivery
Stents
Kinetics

Keywords

  • anisotropic diffusion
  • biological tissue
  • drug delivery

Cite this

McGinty, S., Wheel, M., McKee, S., McCormick, C., McKittrick, C., Kennedy, S., & Oldroyd, K. G. (2015). Can anisotropy enhance the spatial uniformity of drug distribution in biological tissue? . In P. Nithiarasu, & E. Budyn (Eds.), 4th International Conference on Computational & Mathematical Biomedical Engineering (pp. 194-197). Swansea.
McGinty, Sean ; Wheel, Marcus ; McKee, Sean ; McCormick, Christopher ; McKittrick, Craig ; Kennedy, Simon ; Oldroyd, Keith G. / Can anisotropy enhance the spatial uniformity of drug distribution in biological tissue? . 4th International Conference on Computational & Mathematical Biomedical Engineering. editor / Perumal Nithiarasu ; Elisa Budyn. Swansea, 2015. pp. 194-197
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McGinty, S, Wheel, M, McKee, S, McCormick, C, McKittrick, C, Kennedy, S & Oldroyd, KG 2015, Can anisotropy enhance the spatial uniformity of drug distribution in biological tissue? . in P Nithiarasu & E Budyn (eds), 4th International Conference on Computational & Mathematical Biomedical Engineering. Swansea, pp. 194-197, 4th International Conference on Computational & Mathematical Biomedical Engineering, Paris, France, 29/06/15.

Can anisotropy enhance the spatial uniformity of drug distribution in biological tissue? . / McGinty, Sean; Wheel, Marcus; McKee, Sean; McCormick, Christopher; McKittrick, Craig; Kennedy, Simon; Oldroyd, Keith G.

4th International Conference on Computational & Mathematical Biomedical Engineering. ed. / Perumal Nithiarasu; Elisa Budyn. Swansea, 2015. p. 194-197.

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

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McGinty S, Wheel M, McKee S, McCormick C, McKittrick C, Kennedy S et al. Can anisotropy enhance the spatial uniformity of drug distribution in biological tissue? . In Nithiarasu P, Budyn E, editors, 4th International Conference on Computational & Mathematical Biomedical Engineering. Swansea. 2015. p. 194-197