Callyaerin g, a new cytotoxic cyclic peptide from the marine sponge callyspongia aerizusa

S.R.M. Ibrahim, R.A. Edrada-Ebel, G.A. Mohamed, D.T.A. Youssef, V. Wray, P. Proksch

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

From the ethyl acetate fraction of the Indonesian sponge Callyspongia aerizusa extract, a new cyclic peptide named callyaerin G was isolated. Its structure was elucidated by extensive 1D and 2D NMR (1H NMR, TOCSY and ROESY) studies and mass spectrometric data (ESI- and FAB-MS). The stereochemistry was determined by Marfey's analysis. Callyaerin G was found to exhibit cytotoxic activity when tested against different cancer cell lines.
Original languageEnglish
Pages (from-to)164-171
Number of pages7
JournalARKIVOC - Online Journal of Organic Chemistry
Publication statusPublished - 16 Apr 2008

Keywords

  • callyspongia aerizusa
  • callyaerin G
  • marfey's analysis
  • cytotoxicity

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