From the ethyl acetate fraction of the Indonesian sponge Callyspongia aerizusa extract, a new cyclic peptide named callyaerin G was isolated. Its structure was elucidated by extensive 1D and 2D NMR (1H NMR, TOCSY and ROESY) studies and mass spectrometric data (ESI- and FAB-MS). The stereochemistry was determined by Marfey's analysis. Callyaerin G was found to exhibit cytotoxic activity when tested against different cancer cell lines.
|Number of pages||7|
|Journal||ARKIVOC - Online Journal of Organic Chemistry|
|Publication status||Published - 16 Apr 2008|
- callyspongia aerizusa
- callyaerin G
- marfey's analysis
Ibrahim, S. R. M., Edrada-Ebel, R. A., Mohamed, G. A., Youssef, D. T. A., Wray, V., & Proksch, P. (2008). Callyaerin g, a new cytotoxic cyclic peptide from the marine sponge callyspongia aerizusa. ARKIVOC - Online Journal of Organic Chemistry, 164-171.