Calcium signalling in cardiac fibroblasts and myocytes in an in vitro model of HFpEF

Zainab O. Olatunji; Susan Currie; Niall Macquaide

Calcium signalling in cardiac fibroblasts and myocytes in an in vitro model of HFpEF

Zainab O. Olatunji, Susan Currie, Niall Macquaide

Strathclyde Institute Of Pharmacy And Biomedical Sciences

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Abstract

Heart Failure with preserved Ejection Fraction [HFpEF] is a pandemic associated with hypertension and diabetes amongst other co-morbidities1. It has been established that fibrosis plays a major role in this form of heart failure2. However, the functional mechanisms of cardiac fibroblasts (CFs) in HFpEF and more importantly, how these cells interact with cardiomyocytes (CMs) and impact calcium (Ca2+) signalling is limited. This limitations majorly due to a lack of physiologically relevant cellular models.

Original language	English
Number of pages	1
Publication status	Published - 11 Sept 2023
Event	Physiological Society - cross talk of cells in the heart - University of Liverpool Duration: 11 Sept 2023 → 12 Sept 2023

Conference

Conference	Physiological Society - cross talk of cells in the heart
Period	11/09/23 → 12/09/23

Keywords

cardiac fibroblasts
cardiac myociyte
in vitro models

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Olatunji-etal-PS-2023-Calcium-signalling-in-cardiac-fibroblastsAccepted author manuscript, 878 KBLicence: Strath_1

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title = "Calcium signalling in cardiac fibroblasts and myocytes in an in vitro model of HFpEF",

abstract = "Heart Failure with preserved Ejection Fraction [HFpEF] is a pandemic associated with hypertension and diabetes amongst other co-morbidities1. It has been established that fibrosis plays a major role in this form of heart failure2. However, the functional mechanisms of cardiac fibroblasts (CFs) in HFpEF and more importantly, how these cells interact with cardiomyocytes (CMs) and impact calcium (Ca2+) signalling is limited. This limitations majorly due to a lack of physiologically relevant cellular models.",

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AU - Olatunji, Zainab O.

AU - Currie, Susan

AU - Macquaide, Niall

PY - 2023/9/11

Y1 - 2023/9/11

N2 - Heart Failure with preserved Ejection Fraction [HFpEF] is a pandemic associated with hypertension and diabetes amongst other co-morbidities1. It has been established that fibrosis plays a major role in this form of heart failure2. However, the functional mechanisms of cardiac fibroblasts (CFs) in HFpEF and more importantly, how these cells interact with cardiomyocytes (CMs) and impact calcium (Ca2+) signalling is limited. This limitations majorly due to a lack of physiologically relevant cellular models.

AB - Heart Failure with preserved Ejection Fraction [HFpEF] is a pandemic associated with hypertension and diabetes amongst other co-morbidities1. It has been established that fibrosis plays a major role in this form of heart failure2. However, the functional mechanisms of cardiac fibroblasts (CFs) in HFpEF and more importantly, how these cells interact with cardiomyocytes (CMs) and impact calcium (Ca2+) signalling is limited. This limitations majorly due to a lack of physiologically relevant cellular models.

KW - cardiac fibroblasts

KW - cardiac myociyte

KW - in vitro models

M3 - Poster

T2 - Physiological Society - cross talk of cells in the heart

Y2 - 11 September 2023 through 12 September 2023

ER -

Calcium signalling in cardiac fibroblasts and myocytes in an in vitro model of HFpEF

Abstract

Conference

Keywords

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