Projects per year
Abstract
In smooth muscle, Ca2+ release from the internal store into the cytoplasm occurs via inositol trisphosphate (IP3R) and ryanodine receptors (RyR). The internal Ca2+ stores containing IP3R and RyR may be arranged as multiple separate compartments with various IP3R and RyR arrangements, or there may be a single structure containing both receptors. The existence of multiple stores is proposed to explain several physiological responses which include the progression of Ca2+ waves, graded Ca2+ release from the store and various local responses and sensitivities. We suggest that, rather than multiple stores, a single luminally-continuous store exists in which Ca2+ is in free diffusional equilibrium throughout. Regulation of Ca2+ release via IP3R and RyR by the local Ca2+ concentration within the stores explains the apparent existence of multiple stores and physiological processes such as graded Ca2+ release and Ca2+ waves. Close positioning of IP3R on the store with mitochondria or with receptors on the plasma membrane creates ‘IP3 junctions’ to generate local responses on the luminally-continuous store.
Original language | English |
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Title of host publication | Vascular Ion Channels in Physiology and Disease |
Place of Publication | Berlin |
Publisher | Springer |
Pages | 233-254 |
Number of pages | 22 |
ISBN (Electronic) | 978-3-319-29635-7 |
ISBN (Print) | 978-3-319-29633-3 |
DOIs | |
Publication status | Published - 7 Jul 2016 |
Keywords
- smooth muscle
- intracellular ion channels
- inositol trisphosphate
- ryanodine receptors
- IP3R
- RyR
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Dive into the research topics of 'Calcium mobilization via intracellular ion channels, store organization and mitochondria in smooth muscle'. Together they form a unique fingerprint.Projects
- 2 Finished
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Imaging changes in mitochondrial architecture and mobility in vascular disease
McCarron, J. (Principal Investigator), Chalmers, S. (Co-investigator) & Coats, P. (Co-investigator)
6/02/12 → 30/07/15
Project: Research
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Targeting Ca2 + Signals in intact native smooth muscle cells
McCarron, J. (Principal Investigator)
9/08/10 → 8/05/17
Project: Research