Calcium mobilization via intracellular ion channels, store organization and mitochondria in smooth muscle

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In smooth muscle, Ca2+ release from the internal store into the cytoplasm occurs via inositol trisphosphate (IP3R) and ryanodine receptors (RyR). The internal Ca2+ stores containing IP3R and RyR may be arranged as multiple separate compartments with various IP3R and RyR arrangements, or there may be a single structure containing both receptors. The existence of multiple stores is proposed to explain several physiological responses which include the progression of Ca2+ waves, graded Ca2+ release from the store and various local responses and sensitivities. We suggest that, rather than multiple stores, a single luminally-continuous store exists in which Ca2+ is in free diffusional equilibrium throughout. Regulation of Ca2+ release via IP3R and RyR by the local Ca2+ concentration within the stores explains the apparent existence of multiple stores and physiological processes such as graded Ca2+ release and Ca2+ waves. Close positioning of IP3R on the store with mitochondria or with receptors on the plasma membrane creates ‘IP3 junctions’ to generate local responses on the luminally-continuous store.
LanguageEnglish
Title of host publicationVascular Ion Channels in Physiology and Disease
Place of PublicationBerlin
PublisherSpringer
Pages233-254
Number of pages22
ISBN (Electronic)978-3-319-29635-7
ISBN (Print)978-3-319-29633-3
DOIs
Publication statusPublished - 7 Jul 2016

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Ryanodine Receptor Calcium Release Channel
Mitochondria
Ion Channels
Smooth Muscle
Muscle
Calcium
Physiological Phenomena
Inositol
Cell membranes
Cytoplasm
Cell Membrane

Keywords

  • smooth muscle
  • intracellular ion channels
  • inositol trisphosphate
  • ryanodine receptors
  • IP3R
  • RyR

Cite this

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title = "Calcium mobilization via intracellular ion channels, store organization and mitochondria in smooth muscle",
abstract = "In smooth muscle, Ca2+ release from the internal store into the cytoplasm occurs via inositol trisphosphate (IP3R) and ryanodine receptors (RyR). The internal Ca2+ stores containing IP3R and RyR may be arranged as multiple separate compartments with various IP3R and RyR arrangements, or there may be a single structure containing both receptors. The existence of multiple stores is proposed to explain several physiological responses which include the progression of Ca2+ waves, graded Ca2+ release from the store and various local responses and sensitivities. We suggest that, rather than multiple stores, a single luminally-continuous store exists in which Ca2+ is in free diffusional equilibrium throughout. Regulation of Ca2+ release via IP3R and RyR by the local Ca2+ concentration within the stores explains the apparent existence of multiple stores and physiological processes such as graded Ca2+ release and Ca2+ waves. Close positioning of IP3R on the store with mitochondria or with receptors on the plasma membrane creates ‘IP3 junctions’ to generate local responses on the luminally-continuous store.",
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author = "McCarron, {John G.} and Susan Chalmers and Calum Wilson and Sandison, {Mairi E.}",
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Calcium mobilization via intracellular ion channels, store organization and mitochondria in smooth muscle. / McCarron, John G.; Chalmers, Susan; Wilson, Calum; Sandison, Mairi E.

Vascular Ion Channels in Physiology and Disease. Berlin : Springer, 2016. p. 233-254.

Research output: Chapter in Book/Report/Conference proceedingChapter

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AB - In smooth muscle, Ca2+ release from the internal store into the cytoplasm occurs via inositol trisphosphate (IP3R) and ryanodine receptors (RyR). The internal Ca2+ stores containing IP3R and RyR may be arranged as multiple separate compartments with various IP3R and RyR arrangements, or there may be a single structure containing both receptors. The existence of multiple stores is proposed to explain several physiological responses which include the progression of Ca2+ waves, graded Ca2+ release from the store and various local responses and sensitivities. We suggest that, rather than multiple stores, a single luminally-continuous store exists in which Ca2+ is in free diffusional equilibrium throughout. Regulation of Ca2+ release via IP3R and RyR by the local Ca2+ concentration within the stores explains the apparent existence of multiple stores and physiological processes such as graded Ca2+ release and Ca2+ waves. Close positioning of IP3R on the store with mitochondria or with receptors on the plasma membrane creates ‘IP3 junctions’ to generate local responses on the luminally-continuous store.

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