TY - JOUR
T1 - Ca2+-signalling pathways involved in P2X receptor-induced contractions of rat small pulmonary artery
AU - Kennedy, Charles
AU - Syed, Nawazish-i-Husain
N1 - Also published in: Fundamental & Clinical Pharmacology (2008), 22 (S2), p76.
PY - 2008/5
Y1 - 2008/5
N2 - P2X receptors are Ca2+-permeable, ligand-gated cation channels, which are activated by ATP. In arteries, including the rat small pulmonary artery (SPA), they elicit vasoconstriction (Chootip et al., 2002), which is dependent upon extracellular Ca2+. The aim of this study was to determine the relative contributions of Ca2+ influx via the P2X receptor pore and voltage-dependent CaV1.2 (L-type) Ca2+ channels, and the role of Ca2+-induced Ca2+ release (CICR) in P2X receptormediated contractions of rat SPA.
AB - P2X receptors are Ca2+-permeable, ligand-gated cation channels, which are activated by ATP. In arteries, including the rat small pulmonary artery (SPA), they elicit vasoconstriction (Chootip et al., 2002), which is dependent upon extracellular Ca2+. The aim of this study was to determine the relative contributions of Ca2+ influx via the P2X receptor pore and voltage-dependent CaV1.2 (L-type) Ca2+ channels, and the role of Ca2+-induced Ca2+ release (CICR) in P2X receptormediated contractions of rat SPA.
KW - Ca2+-signalling pathways
KW - P2X
KW - receptor-induced contractions
KW - rat
KW - small pulmonary artery
KW - ligand-gated cation channels
KW - ATP
UR - http://dx.doi.org/10.1007/s11302-008-9116-
M3 - Conference Contribution
VL - 4
SP - S201-S201
JO - Purinergic Signalling
JF - Purinergic Signalling
SN - 1573-9538
IS - S1
ER -