Abstract
P2X receptors are Ca2+-permeable, ligand-gated cation channels, which are activated by ATP. In arteries, including the rat small pulmonary artery (SPA), they elicit vasoconstriction (Chootip et al., 2002), which is dependent upon extracellular Ca2+. The aim of this study was to determine the relative contributions of Ca2+ influx via the P2X receptor pore and voltage-dependent CaV1.2 (L-type) Ca2+ channels, and the role of Ca2+-induced Ca2+ release (CICR) in P2X receptormediated contractions of rat SPA.
| Original language | English |
|---|---|
| Pages (from-to) | S201-S201 |
| Journal | Purinergic Signalling |
| Volume | 4 |
| Issue number | S1 |
| Publication status | Published - May 2008 |
Keywords
- Ca2+-signalling pathways
- P2X
- receptor-induced contractions
- rat
- small pulmonary artery
- ligand-gated cation channels
- ATP
Cite this
Kennedy, C., & Syed, N-H. (2008). Ca2+-signalling pathways involved in P2X receptor-induced contractions of rat small pulmonary artery. Purinergic Signalling, 4(S1), S201-S201.