Building GLUT4 vesicles: CHC22 clathrin's human touch

Gwyn W. Gould, Frances M. Brodsky, Nia J. Bryant

Research output: Contribution to journalReview articlepeer-review

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Insulin stimulates glucose transport by triggering regulated delivery of intracellular vesicles containing the GLUT4 glucose transporter to the plasma membrane. This process is defective in diseases such as type 2 diabetes (T2DM). While studies in rodent cells have been invaluable in understanding GLUT4 traffic, evolutionary plasticity must be considered when extrapolating these findings to humans. Recent work has identified species-specific distinctions in GLUT4 traffic, notably the participation of a novel clathrin isoform, CHC22, in humans but not rodents. Here, we discuss GLUT4 sorting in different species and how studies of CHC22 have identified new routes for GLUT4 trafficking. We further consider how different sorting-protein complexes relate to these routes and discuss other implications of these pathways in cell biology and disease.

Original languageEnglish
Pages (from-to)705-719
Number of pages15
JournalTrends in Cell Biology
Issue number9
Early online date30 Jun 2020
Publication statusPublished - 1 Sep 2020


  • GLUT4
  • insulin
  • CHC22 clathrin
  • membrane trafficking
  • diabetes


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