Abstract
| Language | English |
|---|---|
| Pages | 118-143 |
| Number of pages | 26 |
| Journal | International Journal of Multiphase Flow |
| Volume | 90 |
| Early online date | 1 Dec 2016 |
| DOIs | |
| Publication status | Published - 30 Apr 2017 |
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Keywords
- bubble dynamics
- drug delivery
- sonoporation
- spectral element
- marker particle method
- bioengineering
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Bubble collapse near a fluid-fluid interface using the spectral element marker particle method with applications in bioengineering. / Rowlatt, Christopher F.; Lind, Steven J.
In: International Journal of Multiphase Flow, Vol. 90, 30.04.2017, p. 118-143.Research output: Contribution to journal › Article
TY - JOUR
T1 - Bubble collapse near a fluid-fluid interface using the spectral element marker particle method with applications in bioengineering
AU - Rowlatt, Christopher F.
AU - Lind, Steven J.
PY - 2017/4/30
Y1 - 2017/4/30
N2 - The spectral element marker particle (SEMP) method is a high-order numerical scheme for modelling multiphase flow where the governing equations are discretised using the spectral element method and the (compressible) fluid phases are tracked using marker particles. Thus far, the method has been successfully applied to two-phase problems involving the collapse of a two-dimensional bubble in the vicinity of a rigid wall. In this article, the SEMP method is extended to include a third fluid phase before being applied to bubble collapse problems near a fluid-fluid interface. Two-phase bubble collapse near a rigid boundary (where a highly viscous third phase approximates the rigid boundary) is considered as validation of the method. A range of fluid parameter values and geometric configurations are studied before a bioengineering application is considered. A simplified model of (micro)bubble-cell interaction is presented, with the aim of gaining initial insights into the flow mechanisms behind sonoporation and microbubble-enhanced targeted drug delivery. Results from this model indicate that the non-local cell membrane distortion (blebbing) phenomenon often observed experimentally may result from stress propagation along the cell surface and so be hydrodynamical in origin.
AB - The spectral element marker particle (SEMP) method is a high-order numerical scheme for modelling multiphase flow where the governing equations are discretised using the spectral element method and the (compressible) fluid phases are tracked using marker particles. Thus far, the method has been successfully applied to two-phase problems involving the collapse of a two-dimensional bubble in the vicinity of a rigid wall. In this article, the SEMP method is extended to include a third fluid phase before being applied to bubble collapse problems near a fluid-fluid interface. Two-phase bubble collapse near a rigid boundary (where a highly viscous third phase approximates the rigid boundary) is considered as validation of the method. A range of fluid parameter values and geometric configurations are studied before a bioengineering application is considered. A simplified model of (micro)bubble-cell interaction is presented, with the aim of gaining initial insights into the flow mechanisms behind sonoporation and microbubble-enhanced targeted drug delivery. Results from this model indicate that the non-local cell membrane distortion (blebbing) phenomenon often observed experimentally may result from stress propagation along the cell surface and so be hydrodynamical in origin.
KW - bubble dynamics
KW - drug delivery
KW - sonoporation
KW - spectral element
KW - marker particle method
KW - bioengineering
U2 - 10.1016/j.ijmultiphaseflow.2016.11.010
DO - 10.1016/j.ijmultiphaseflow.2016.11.010
M3 - Article
VL - 90
SP - 118
EP - 143
JO - International Journal of Multiphase Flow
T2 - International Journal of Multiphase Flow
JF - International Journal of Multiphase Flow
SN - 0301-9322
ER -