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Abstract
Herein, we report the decarboxylative Minisci heteroarylation of bicyclo[1.1.1]pentane (BCP) and 2-oxabicyclo[2.1.1]hexane (oBCH) derivatives at the bridge positions. In an operationally simple, photocatalyst-free process, free bridge carboxylic acids are directly coupled with nonprefunctionalized heteroarenes to provide rare examples of polysubstituted BCP and oBCH derivatives in synthetically useful yields. Additionally, the impact of the BCP core on the physicochemical properties of a representative example compared to those of its all-aromatic ortho- and meta-substituted analogues is evaluated.
Original language | English |
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Pages (from-to) | 2053–2057 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 25 |
Issue number | 12 |
Early online date | 17 Mar 2023 |
DOIs | |
Publication status | Published - 31 Mar 2023 |
Keywords
- bridge heteroarylation
- bicyclo[1.1.1]pentane derivatives
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Dive into the research topics of 'Bridge heteroarylation of bicyclo[1.1.1]pentane derivatives'. Together they form a unique fingerprint.Projects
- 1 Finished
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PP: Accelerated Discovery and Development of New Medicines: Prosperity Partnership for a Healthier Nation
Murphy, J. (Co-investigator) & Bell, J. (Researcher)
1/01/19 → 31/12/23
Project: Research