Breast cancer survival analysis with molecular subtypes: an initial step

Lingli Zhang, Jiaiun Wu, Youbing Zhao, Wenxian Hu, Aihong Qin, Feng Dong, Enjie Liu, Hao Zeng, Hao Xie, Hui Du

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

1 Citation (Scopus)
34 Downloads (Pure)

Abstract

As a predominant threat to women's health world-wide, breast cancer has become increasingly important in on-cology research. The discovery of molecular subtypes of breast cancer has led to more subtype oriented treatment and prognosis prediction. Effective prognosis models help to estimate the recurrence as well as the quality and duration of survival, leading to more personalized treatments. However, most traditional prognostic models either ignore molecular subtypes or only make limited use of them. The roles of molecular subtypes in the development and treatment of breast cancer have not been fully revealed. With the over 1200 cases collected by Sir Run Run Shaw Hospital of Zhejiang University in the past two decades, we aim to improve understanding of molecular subtypes and their impacts on the prognosis via data analysis in the long run. As the initial stage, this short paper presents our preliminary work of logistic regression experiments with the data. Though molecular subtypes have not been included the tentative model, they are to be explored further in following stages.
Original languageEnglish
Title of host publication2022 IEEE 22nd International Conference on Bioinformatics and Bioengineering (BIBE)
Place of PublicationPiscataway, NJ
PublisherIEEE
Pages363-366
Number of pages4
ISBN (Electronic)9781665484879
ISBN (Print)9781665484886
DOIs
Publication statusPublished - 14 Nov 2022
EventIEEE 22nd International Conference on Bioinformatics and Bioengineering (BIBE) - https://bibe2022.asia.edu.tw/, Taichung, Taiwan
Duration: 7 Nov 20229 Nov 2022
https://bibe2022.asia.edu.tw/

Publication series

Name2022 IEEE 22nd International Conference on Bioinformatics and Bioengineering (BIBE)
PublisherIEEE

Conference

ConferenceIEEE 22nd International Conference on Bioinformatics and Bioengineering (BIBE)
Abbreviated titleBIBE 2022
Country/TerritoryTaiwan
CityTaichung
Period7/11/229/11/22
Internet address

Keywords

  • breast cancer
  • prognostic models
  • survival analysis
  • logistic regression
  • molecular subtypes

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