Brain delivery of peptides and proteins

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Therapeutic proteins and peptides have been identified as showing great promise for the treatment of brain cancers and neurodegenerative diseases. However, their delivery to their intended site of action from the blood is hampered by the presence of the blood-brain barrier (BBB), a vital element in the regulation of the internal environment of the brain and the spinal cord. Peptides generally do not cross the BBB because these highly polar compounds are not lipid-soluble, and because most circulating peptides do not have access to specialized, BBB receptor-mediated transport systems. Over the past three decades, research has led to a better understanding of the transport mechanisms at the BBB, and to the development of several strategies for improving the delivery of peptides/proteins to the central nervous system (CNS).
Original languageEnglish
Title of host publicationPeptide and protein delivery
EditorsChristopher van der Walle
Pages105-122
Number of pages18
Volume1
Edition1st
DOIs
Publication statusPublished - 2011

Keywords

  • therapeutic proteins
  • peptides
  • brain
  • brain cancers
  • blood-brain barrier

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    Dufès, C. (2011). Brain delivery of peptides and proteins. In C. van der Walle (Ed.), Peptide and protein delivery (1st ed., Vol. 1, pp. 105-122) https://doi.org/10.1016/B978-0-12-384935-9.10006-9