TY - JOUR
T1 - Brain activation in highly superior autobiographical memory
T2 - the role of the precuneus in the autobiographical memory retrieval network
AU - Mazzoni, Giuliana
AU - Clark, Andrew
AU - De Bartolo, Adriana
AU - Guerrini, Chiara
AU - Nahouli, Zacharia
AU - Duzzi, Davide
AU - De Marco, Matteo
AU - McGeown, William
AU - Venneri, Annalena
PY - 2019/11/1
Y1 - 2019/11/1
N2 - This is the first study to examine functional brain activation in a single case of Highly Superior Autobiographical Memory (HSAM) who shows no sign of obsessive compulsive disorder (OCD). While previous work has documented the existence of HSAM, information about brain areas involved in this exceptional form of memory for personal events relies on structural and resting state connectivity data, with mixed results so far. In this first task-based functional magnetic resonance Imaging (fMRI) study of a normal individual with HSAM, dates were presented as cues and two phases were assessed during memory retrieval, initial access and later elaboration. Results showed that initial access was very fast, did not activate the hippocampus, and involved activation of predominantly posterior visual areas, including the precuneus. These areas typically become active during later stages of elaboration of personal memories rather than during initial access. Elaboration involved a balanced bilateral activation of most of the autobiographical network areas, rather than the more typical shifts observed in people without HSAM. Overall, the pattern of brain activations, which rests on repeated observations in a single individual, highlights a strong involvement of the precuneus and an idiosyncratic initial access to personal memory representations. Implications for the nature of personal memories in HSAM are discussed.
AB - This is the first study to examine functional brain activation in a single case of Highly Superior Autobiographical Memory (HSAM) who shows no sign of obsessive compulsive disorder (OCD). While previous work has documented the existence of HSAM, information about brain areas involved in this exceptional form of memory for personal events relies on structural and resting state connectivity data, with mixed results so far. In this first task-based functional magnetic resonance Imaging (fMRI) study of a normal individual with HSAM, dates were presented as cues and two phases were assessed during memory retrieval, initial access and later elaboration. Results showed that initial access was very fast, did not activate the hippocampus, and involved activation of predominantly posterior visual areas, including the precuneus. These areas typically become active during later stages of elaboration of personal memories rather than during initial access. Elaboration involved a balanced bilateral activation of most of the autobiographical network areas, rather than the more typical shifts observed in people without HSAM. Overall, the pattern of brain activations, which rests on repeated observations in a single individual, highlights a strong involvement of the precuneus and an idiosyncratic initial access to personal memory representations. Implications for the nature of personal memories in HSAM are discussed.
KW - autobiographical memory network
KW - Highly Superior Autobiographical Memory (HSAM)
KW - brain imaging
KW - praecuneus
UR - https://www.sciencedirect.com/journal/cortex
U2 - 10.1016/j.cortex.2019.02.020
DO - 10.1016/j.cortex.2019.02.020
M3 - Article
SN - 0010-9452
VL - 120
SP - 588
EP - 602
JO - Cortex
JF - Cortex
ER -