Boron phenylalanine and related impurities: HPLC analysis, stability profile and degradation pathways

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3 Citations (Scopus)

Abstract

Boron phenylalanine is one of the lead drug candidates in the field of Boron Neutron Capture Therapy. Its inherent low toxicity allows large doses to be administered, but this makes it important to identify, rationalise and quantify impurities. Here we report a chromatographic assay method, the conditions under which the parent compound is unstable, and the suggested degradation mechanisms.
LanguageEnglish
Pages633-636
Number of pages4
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume56
Issue number3
Early online date1 Jul 2011
DOIs
Publication statusPublished - 1 Nov 2011

Fingerprint

Boron Neutron Capture Therapy
Boron
Phenylalanine
High Pressure Liquid Chromatography
Impurities
Degradation
Pharmaceutical Preparations
Toxicity
Assays
Neutrons
Lead

Keywords

  • BPA
  • degradation
  • impurities
  • HPLC
  • BNCT

Cite this

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abstract = "Boron phenylalanine is one of the lead drug candidates in the field of Boron Neutron Capture Therapy. Its inherent low toxicity allows large doses to be administered, but this makes it important to identify, rationalise and quantify impurities. Here we report a chromatographic assay method, the conditions under which the parent compound is unstable, and the suggested degradation mechanisms.",
keywords = "BPA, degradation, impurities, HPLC, BNCT",
author = "Lindsay Dick and Neil Dooley and Elliott, {Moira A} and Ford, {Steven J} and Gordon, {Malcolm R} and Halbert, {Gavin W} and Kerr, {William J}",
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AU - Dick, Lindsay

AU - Dooley, Neil

AU - Elliott, Moira A

AU - Ford, Steven J

AU - Gordon, Malcolm R

AU - Halbert, Gavin W

AU - Kerr, William J

N1 - Copyright © 2011 Elsevier B.V. All rights reserved.

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Boron phenylalanine is one of the lead drug candidates in the field of Boron Neutron Capture Therapy. Its inherent low toxicity allows large doses to be administered, but this makes it important to identify, rationalise and quantify impurities. Here we report a chromatographic assay method, the conditions under which the parent compound is unstable, and the suggested degradation mechanisms.

AB - Boron phenylalanine is one of the lead drug candidates in the field of Boron Neutron Capture Therapy. Its inherent low toxicity allows large doses to be administered, but this makes it important to identify, rationalise and quantify impurities. Here we report a chromatographic assay method, the conditions under which the parent compound is unstable, and the suggested degradation mechanisms.

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KW - degradation

KW - impurities

KW - HPLC

KW - BNCT

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