Boron phenylalanine and related impurities: HPLC analysis, stability profile and degradation pathways

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Boron phenylalanine is one of the lead drug candidates in the field of Boron Neutron Capture Therapy. Its inherent low toxicity allows large doses to be administered, but this makes it important to identify, rationalise and quantify impurities. Here we report a chromatographic assay method, the conditions under which the parent compound is unstable, and the suggested degradation mechanisms.
Original languageEnglish
Pages (from-to)633-636
Number of pages4
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume56
Issue number3
Early online date1 Jul 2011
DOIs
Publication statusPublished - 1 Nov 2011

Keywords

  • BPA
  • degradation
  • impurities
  • HPLC
  • BNCT

Fingerprint Dive into the research topics of 'Boron phenylalanine and related impurities: HPLC analysis, stability profile and degradation pathways'. Together they form a unique fingerprint.

  • Cite this