Boron phenylalanine and related impurities: HPLC analysis, stability profile and degradation pathways

Lindsay Dick; Neil Dooley; Moira A Elliott; Steven J Ford; Malcolm R Gordon; Gavin W Halbert; William J Kerr

doi:10.1016/j.jpba.2011.06.025

Boron phenylalanine and related impurities: HPLC analysis, stability profile and degradation pathways

Lindsay Dick, Neil Dooley, Moira A Elliott, Steven J Ford, Malcolm R Gordon, Gavin W Halbert, William J Kerr

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Boron phenylalanine is one of the lead drug candidates in the field of Boron Neutron Capture Therapy. Its inherent low toxicity allows large doses to be administered, but this makes it important to identify, rationalise and quantify impurities. Here we report a chromatographic assay method, the conditions under which the parent compound is unstable, and the suggested degradation mechanisms.

Original language	English
Pages (from-to)	633-636
Number of pages	4
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	56
Issue number	3
Early online date	1 Jul 2011
DOIs	https://doi.org/10.1016/j.jpba.2011.06.025
Publication status	Published - 1 Nov 2011

Keywords

BPA
degradation
impurities
HPLC
BNCT

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10.1016/j.jpba.2011.06.025

Cite this

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abstract = "Boron phenylalanine is one of the lead drug candidates in the field of Boron Neutron Capture Therapy. Its inherent low toxicity allows large doses to be administered, but this makes it important to identify, rationalise and quantify impurities. Here we report a chromatographic assay method, the conditions under which the parent compound is unstable, and the suggested degradation mechanisms.",

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AU - Dooley, Neil

AU - Elliott, Moira A

AU - Ford, Steven J

AU - Gordon, Malcolm R

AU - Halbert, Gavin W

AU - Kerr, William J

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Boron phenylalanine is one of the lead drug candidates in the field of Boron Neutron Capture Therapy. Its inherent low toxicity allows large doses to be administered, but this makes it important to identify, rationalise and quantify impurities. Here we report a chromatographic assay method, the conditions under which the parent compound is unstable, and the suggested degradation mechanisms.

AB - Boron phenylalanine is one of the lead drug candidates in the field of Boron Neutron Capture Therapy. Its inherent low toxicity allows large doses to be administered, but this makes it important to identify, rationalise and quantify impurities. Here we report a chromatographic assay method, the conditions under which the parent compound is unstable, and the suggested degradation mechanisms.

KW - BPA

KW - degradation

KW - impurities

KW - HPLC

KW - BNCT

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DO - 10.1016/j.jpba.2011.06.025

M3 - Article

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ER -

Boron phenylalanine and related impurities: HPLC analysis, stability profile and degradation pathways

Abstract

Keywords

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