Blood interactions with plasticised poly (vinyl chloride): influence of surface modification

X.B. Zhao, J.M. Courtney, H.Q. Yin, R.H. West, G.D.O. Lowe

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Surface modification of plasticised poly (vinyl chloride) (PVC), with di-(2-ethylhexyl) phthalate (DEHP) as plasticiser, for the improvement of blood compatibility in potential clinical use such as cardiopulmonary bypass was achieved by heparinisation. The influence of surface modification on blood compatibility was assessed in terms of the influence on fibrinogen and factor XII adsorption in vitro, and the generation of thrombin-antithrombin III complex (TAT) and the complement component C3a, in vitro and ex vivo. Electron spectroscopy for chemical analysis (ESCA) was used to characterise the heparinised surface in order to correlate the surface properties with the blood response. Results indicate that at the plasticised PVC surface there is a higher content of heparin than that of the PVC and the DEHP content is lower than that present at the surface of standard plasticised PVC. The blood compatibility assessment confirms the importance of surface modification for the improvement of blood compatibility.
    LanguageEnglish
    Pages713-719
    Number of pages6
    JournalJournal of Materials Science: Materials in Medicine
    Volume19
    Issue number2
    DOIs
    Publication statusPublished - Feb 2008

    Fingerprint

    Vinyl Chloride
    Polyvinyl Chloride
    Polyvinyl chlorides
    Surface treatment
    Blood
    Complement C3a
    Factor XII
    Plasticizers
    Photoelectron Spectroscopy
    Electron spectroscopy
    Surface Properties
    Cardiopulmonary Bypass
    Fibrinogen
    Adsorption
    Surface properties
    Heparin
    Chemical analysis

    Keywords

    • blood interactions
    • plasticised poly
    • vinyl chloride
    • surface modification

    Cite this

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    title = "Blood interactions with plasticised poly (vinyl chloride): influence of surface modification",
    abstract = "Surface modification of plasticised poly (vinyl chloride) (PVC), with di-(2-ethylhexyl) phthalate (DEHP) as plasticiser, for the improvement of blood compatibility in potential clinical use such as cardiopulmonary bypass was achieved by heparinisation. The influence of surface modification on blood compatibility was assessed in terms of the influence on fibrinogen and factor XII adsorption in vitro, and the generation of thrombin-antithrombin III complex (TAT) and the complement component C3a, in vitro and ex vivo. Electron spectroscopy for chemical analysis (ESCA) was used to characterise the heparinised surface in order to correlate the surface properties with the blood response. Results indicate that at the plasticised PVC surface there is a higher content of heparin than that of the PVC and the DEHP content is lower than that present at the surface of standard plasticised PVC. The blood compatibility assessment confirms the importance of surface modification for the improvement of blood compatibility.",
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    Blood interactions with plasticised poly (vinyl chloride): influence of surface modification. / Zhao, X.B.; Courtney, J.M.; Yin, H.Q.; West, R.H.; Lowe, G.D.O.

    In: Journal of Materials Science: Materials in Medicine, Vol. 19, No. 2, 02.2008, p. 713-719.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Blood interactions with plasticised poly (vinyl chloride): influence of surface modification

    AU - Zhao, X.B.

    AU - Courtney, J.M.

    AU - Yin, H.Q.

    AU - West, R.H.

    AU - Lowe, G.D.O.

    PY - 2008/2

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    N2 - Surface modification of plasticised poly (vinyl chloride) (PVC), with di-(2-ethylhexyl) phthalate (DEHP) as plasticiser, for the improvement of blood compatibility in potential clinical use such as cardiopulmonary bypass was achieved by heparinisation. The influence of surface modification on blood compatibility was assessed in terms of the influence on fibrinogen and factor XII adsorption in vitro, and the generation of thrombin-antithrombin III complex (TAT) and the complement component C3a, in vitro and ex vivo. Electron spectroscopy for chemical analysis (ESCA) was used to characterise the heparinised surface in order to correlate the surface properties with the blood response. Results indicate that at the plasticised PVC surface there is a higher content of heparin than that of the PVC and the DEHP content is lower than that present at the surface of standard plasticised PVC. The blood compatibility assessment confirms the importance of surface modification for the improvement of blood compatibility.

    AB - Surface modification of plasticised poly (vinyl chloride) (PVC), with di-(2-ethylhexyl) phthalate (DEHP) as plasticiser, for the improvement of blood compatibility in potential clinical use such as cardiopulmonary bypass was achieved by heparinisation. The influence of surface modification on blood compatibility was assessed in terms of the influence on fibrinogen and factor XII adsorption in vitro, and the generation of thrombin-antithrombin III complex (TAT) and the complement component C3a, in vitro and ex vivo. Electron spectroscopy for chemical analysis (ESCA) was used to characterise the heparinised surface in order to correlate the surface properties with the blood response. Results indicate that at the plasticised PVC surface there is a higher content of heparin than that of the PVC and the DEHP content is lower than that present at the surface of standard plasticised PVC. The blood compatibility assessment confirms the importance of surface modification for the improvement of blood compatibility.

    KW - blood interactions

    KW - plasticised poly

    KW - vinyl chloride

    KW - surface modification

    UR - http://dx.doi.org/10.1007/s10856-007-3191-6

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