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Abstract
Understanding the haemodynamic environment of the pulmonary bifurcation is important in adults with repaired conotruncal congenital heart disease. In these patients, dysfunction of the pulmonary valve and narrowing of the branch pulmonary arteries are common and can have serious clinical consequences. The aim of this study was to numerically investigate the underlying blood flow characteristics in the pulmonary trunk under a range of simplified conditions. For that, an in-depth analysis was conducted in idealised two-dimensional geometries that facilitate parametric investigation of healthy and abnormal conditions. Subtle variations in morphology influenced the haemodynamic environment and wall shear stress distribution. The pressure in the left pulmonary artery was generally higher than that in the right and main arteries, but was markedly reduced in the presence of a local stenosis. Different downstream pressure conditions altered the branch flow ratio, from 50:50% to more realistic 60:40% ratios in the right and left pulmonary artery, respectively. Despite some simplifications, this study highlights some previously undocumented aspects of the flow in bifurcating geometries, by clarifying the role of the stagnation point location on wall shear stress and differential branch pressures. In addition, measurements of the mean pressure ratios in the pulmonary bifurcation are discussed in the context of a new haemodynamic index which could potentially contribute to the assessment of left pulmonary artery stenosis in tetralogy of Fallot patients. Further studies are required to confirm the results in patient-specific models with personalised physiological flow conditions.
Original language | English |
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Pages (from-to) | 123-138 |
Number of pages | 16 |
Journal | Medical Engineering and Physics |
Volume | 85 |
Early online date | 30 Sept 2020 |
DOIs | |
Publication status | Published - 30 Nov 2020 |
Keywords
- computational fluid dynamics
- congenital heart disease
- haemodynamics
- numerical simulations
- tetralogy of Fallot
Fingerprint
Dive into the research topics of 'Blood flow simulations in the pulmonary bifurcation in relation to adult patients with repaired tetralogy of Fallot'. Together they form a unique fingerprint.Projects
- 2 Finished
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Multi-scale computational hemodynamics in obese children and adolescents: enabling personalised prediction of cardiovascular disease (CALLIRHEO) H2020 MSCA IF
Gourlay, T. (Co-investigator) & Kazakidi, A. (Fellow)
European Commission - Horizon Europe + H2020
1/01/18 → 31/12/19
Project: Research Fellowship
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Blood flow dynamics in the surviving adult congenital heart patient
Kazakidi, A. (Principal Investigator), Danton, M. (Research Co-investigator) & Gourlay, T. (Academic)
1/10/17 → 30/09/20
Project: Research - Studentship
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Erratum: blood flow simulations in the pulmonary bifurcation in relation to adult patients with repaired tetralogy of Fallot
Boumpouli, M., Danton, M. H. D., Gourlay, T. & Kazakidi, A., 6 Mar 2021, In: Medical Engineering and Physics . 90, p. 82 1 p.Research output: Contribution to journal › Correction › peer-review
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Hemodynamics in the pulmonary bifurcation: effect of geometry and boundary conditions
Boumpouli, M., Danton, M., Gourlay, T. & Kazakidi, A., 5 Sept 2019. 1 p.Research output: Contribution to conference › Abstract › peer-review
Open AccessFile -
Blood flow in the pulmonary bifurcation under healthy and diseased conditions
Boumpouli, M., Danton, M., Gourlay, T. & Kazakidi, A., 30 May 2019. 1 p.Research output: Contribution to conference › Abstract › peer-review
Open AccessFile