Biovolume calculation and three-dimensional imaging of bovine spermatozoa by digital holography

F. Merola*, L. Miccio, P. Memmolo, G. Di Caprio, G. Coppola, P. Netti, P. Ferraro

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

Abstract

We show an approach exploiting the capability of optical tweezers to trap and put in rotation bovine spermatozoa flowing into a microfluidic channel. At same time, digital holographic microscopy allows to image the cell in phase-contrast modality for each different angular position, during the rotation. From the collected information about the cell's phasecontrast signature, it is possible to reconstruct the 3D shape of the cell and estimate its volume. The method can open new pathways for rapid measurement of in-vitro cells volume in microfluidic lab-on-a-chip platform, thus having access to the 3D structure of the object avoiding tomographic microscopy.

Original languageEnglish
Title of host publicationImaging and Applied Optics - Digital Holography and Three-Dimensional Imaging, DH 2014
Place of PublicationWashington, DC
PublisherOptical Society of America
ISBN (Print)9781557523082
DOIs
Publication statusPublished - 17 Jul 2014
EventDigital Holography and Three-Dimensional Imaging, DH 2014 - Seattle, WA, United States
Duration: 13 Jul 201417 Jul 2014

Publication series

NameOptics InfoBase Conference Papers
ISSN (Electronic)2162-2701

Conference

ConferenceDigital Holography and Three-Dimensional Imaging, DH 2014
Country/TerritoryUnited States
CitySeattle, WA
Period13/07/1417/07/14

Keywords

  • optical tweezers
  • bovine spermatozoa
  • digital holography

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