Biosimilars are essential for sustainable healthcare systems across Europe; however, key challenges remain as seen with biosimilars for long-acting insulin analogues

Brian Godman, Biljana Tubić, Eleonora Allocati, Magdalene Wladysiuk, Stuart McTaggart, Amanj Kurdi, Mainul Haque, Sean MacBride-Stewart, Francis Kalemeera, Amos Massele, Iris Hoxha, Vanda Marković-Peković, Guenka Petrova, Konstantin Tachkov, Ott Laius, András Harsanyi, Andras Inotai, Arianit Jakupi, Svens Henkuzens, Kristina GaruolienėPatricia Vella Bonanno, Jakub Rutkowski, Ileana Mardare, Jurij Fürst, Caridad Pontes, Corinne Zara, Marta Turu Pedrola, Farhana Akter, Hye-Young Kwon, Antony P Martin, Rita Banzi, Janney Wale, Jolanta Gulbinovic

Research output: Contribution to journalArticlepeer-review

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Abstract

Sales of medicines continue to grow world-wide driven in part by increasing expenditures on biological medicines leading to concerns with the long-term sustainability of European healthcare systems. The increasing use of biosimilars at lower costs can potentially address this. However, there can be concerns with their prescribing. There are also concerns with biosimilar insulin glargine including concerns with different devices despite increasing sales of long-acting insulin analogues worldwide. Consequently, a need to appraise the European biosimilar market incorporating measures to enhance their use including potential ways to increase the prescribing of biosimilars of insulin glargine at lower costs. Multiple approaches were used to undertake the study including measures to enhance biosimilar use and their impact across Europe. In addition, undertake cross national research on the utilization and expenditure of long-acting insulin analogues, which includes biosimilars, principally among Central and Eastern European countries. Multiple demand-side measures across countries have enhanced the use of biosimilars. There was variable use of biosimilar insulin glargine 100IU/ml driven by increasing use of patented 300IU/ml formulations and small price differences between the originator and biosimilars in practice. Overall, multiple demand-side initiatives can appreciably increase biosimilar use benefiting all groups. Additional measures are needed to enhance future prescribing of long-acting biosimilar insulin analogues.
Original languageEnglish
Pages (from-to)55-72
Number of pages28
JournalJournal of Applied Pharmaceutical Science
Volume12
Issue number3
DOIs
Publication statusPublished - 31 Mar 2022

Keywords

  • biosimilars
  • insulin glargine
  • prices
  • health policies
  • demand-side measures
  • Europe

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