Bioresponsive hydrogels

Rein V. Ulijn, Nurguse Bibi, Vineetha Jayawarna, Paul D. Thornton, Simon J. Todd, Robert J. Mart, Andrew M. Smith, Julie E. Gough

Research output: Contribution to journalLiterature review

339 Citations (Scopus)

Abstract

We highlight recent developments in hydrogel materials with biological responsiveness built in. These 'smart' biomaterials change properties in response to selective biological recognition events. When exposed to a biological target (nutrient, growth factor, receptor, antibody, enzyme, or whole cell), molecular recognition events trigger changes in molecular interactions that translate into macroscopic responses, such as swelling/collapse or solution-to-gel transitions. The hydrogel transitions may be used directly as optical readouts for biosensing, linked to the release of actives for drug delivery, or instigate biochemical signaling events that control or direct cellular behavior. Accordingly, bioresponsive hydrogels have gained significant interest for application in diagnostics, drug delivery, and tissue regeneration/wound healing.

LanguageEnglish
Pages40-48
Number of pages9
JournalMaterials Today
Volume10
Issue number4
DOIs
Publication statusPublished - Apr 2007

Fingerprint

Hydrogels
Hydrogel
Drug delivery
Molecular recognition
Tissue regeneration
Growth Factor Receptors
Molecular interactions
delivery
Biocompatible Materials
drugs
Nutrients
Swelling
wound healing
Gels
nutrients
molecular interactions
antibodies
regeneration
Antibodies
Biomaterials

Keywords

  • bioresponsive hydrogels
  • photonic crystal
  • supramolecular hydrogel
  • responsive polymers
  • sensitive hydrogels
  • cell migration
  • drug delivery
  • in vivo
  • biomaterials
  • glucose
  • medicine

Cite this

Ulijn, R. V., Bibi, N., Jayawarna, V., Thornton, P. D., Todd, S. J., Mart, R. J., ... Gough, J. E. (2007). Bioresponsive hydrogels. Materials Today, 10(4), 40-48. https://doi.org/10.1016/S1369-7021(07)70049-4
Ulijn, Rein V. ; Bibi, Nurguse ; Jayawarna, Vineetha ; Thornton, Paul D. ; Todd, Simon J. ; Mart, Robert J. ; Smith, Andrew M. ; Gough, Julie E. / Bioresponsive hydrogels. In: Materials Today. 2007 ; Vol. 10, No. 4. pp. 40-48.
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Ulijn, RV, Bibi, N, Jayawarna, V, Thornton, PD, Todd, SJ, Mart, RJ, Smith, AM & Gough, JE 2007, 'Bioresponsive hydrogels' Materials Today, vol. 10, no. 4, pp. 40-48. https://doi.org/10.1016/S1369-7021(07)70049-4

Bioresponsive hydrogels. / Ulijn, Rein V.; Bibi, Nurguse; Jayawarna, Vineetha; Thornton, Paul D.; Todd, Simon J.; Mart, Robert J.; Smith, Andrew M.; Gough, Julie E.

In: Materials Today, Vol. 10, No. 4, 04.2007, p. 40-48.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - Bioresponsive hydrogels

AU - Ulijn, Rein V.

AU - Bibi, Nurguse

AU - Jayawarna, Vineetha

AU - Thornton, Paul D.

AU - Todd, Simon J.

AU - Mart, Robert J.

AU - Smith, Andrew M.

AU - Gough, Julie E.

PY - 2007/4

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N2 - We highlight recent developments in hydrogel materials with biological responsiveness built in. These 'smart' biomaterials change properties in response to selective biological recognition events. When exposed to a biological target (nutrient, growth factor, receptor, antibody, enzyme, or whole cell), molecular recognition events trigger changes in molecular interactions that translate into macroscopic responses, such as swelling/collapse or solution-to-gel transitions. The hydrogel transitions may be used directly as optical readouts for biosensing, linked to the release of actives for drug delivery, or instigate biochemical signaling events that control or direct cellular behavior. Accordingly, bioresponsive hydrogels have gained significant interest for application in diagnostics, drug delivery, and tissue regeneration/wound healing.

AB - We highlight recent developments in hydrogel materials with biological responsiveness built in. These 'smart' biomaterials change properties in response to selective biological recognition events. When exposed to a biological target (nutrient, growth factor, receptor, antibody, enzyme, or whole cell), molecular recognition events trigger changes in molecular interactions that translate into macroscopic responses, such as swelling/collapse or solution-to-gel transitions. The hydrogel transitions may be used directly as optical readouts for biosensing, linked to the release of actives for drug delivery, or instigate biochemical signaling events that control or direct cellular behavior. Accordingly, bioresponsive hydrogels have gained significant interest for application in diagnostics, drug delivery, and tissue regeneration/wound healing.

KW - bioresponsive hydrogels

KW - photonic crystal

KW - supramolecular hydrogel

KW - responsive polymers

KW - sensitive hydrogels

KW - cell migration

KW - drug delivery

KW - in vivo

KW - biomaterials

KW - glucose

KW - medicine

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DO - 10.1016/S1369-7021(07)70049-4

M3 - Literature review

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Ulijn RV, Bibi N, Jayawarna V, Thornton PD, Todd SJ, Mart RJ et al. Bioresponsive hydrogels. Materials Today. 2007 Apr;10(4):40-48. https://doi.org/10.1016/S1369-7021(07)70049-4