Bioreductive molecular probe: fluorescence signalling upon reduction of an azo group

Manikandan Kadirvel, Nicholas J. W. Rattray, Ramkumar Rajendran, Waleed A. Zalloum, Abdul Gbaj, Constantinos Demonacos, Elena V. Bichenkova, Sally Freeman

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The intramolecular heterodimer probe 4-O-dabsyl-2-O-dansyl-myo-inositol-1, 3,5-orthoformate undergoes biomimetic reduction of the azo bond in the dabsyl group to give a fluorescence emission band at 560 nm. This is attributed to the loss of energy transfer between the fluorophore (dansyl) and quencher (dabsyl) groups as a result of the formation of 4-O-(4-aminobenzene sulfonyl)-2-O-dansyl- myo-inositol-1,3,5-orthoformate.

Original languageEnglish
Pages (from-to)701-708
Number of pages8
JournalNew Journal of Chemistry
Volume35
Issue number3
Early online date4 Jan 2011
DOIs
Publication statusPublished - 1 Mar 2011

Keywords

  • fluorescence emission
  • intramolecular heterodimer probe
  • myo-inositol phosphates

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