Biomimetic cancer cell membrane-coated nanosystems as next-generation cancer therapies

Miguel Pereira-Silva, Ana Cláudia Santos, João Conde, Clare Hoskins, Angel Concheiro, Carmen Alvarez-Lorenzo, Francisco Veiga

Research output: Contribution to journalEditorial

Abstract

Cancer ranks amongst the most deadliest diseases, associated with significant burden, often fatal prognosis and huge clinical challenge [1]. Cancer management has substantially improved mainly on cancer diagnostics and therapeutics, resulting in extended survival rates and decreased mortality worldwide. Chemotherapy, along with radiotherapy and surgery, represents one of the major therapeutic approaches for cancer cells eradication, however associated with several shortcomings, as poor cancer tissue biodistribution, accelerated drug degradation and clearance, insufficient cancer targetability and still high systemic toxicity, overall compromising efficacy and safety [2, 3].
Original languageEnglish
JournalExpert Opinion on Drug Delivery
Early online date19 Aug 2020
DOIs
Publication statusE-pub ahead of print - 19 Aug 2020

Keywords

  • biointerfacing
  • biomimetic nanosystems
  • cancer cell membrane
  • cancer cell membrane-coated nanosystems
  • cancer-targeted therapy
  • cell membrane coatings
  • drug delivery

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