Biomaterial development for cardiopulmonary bypass

    Research output: Contribution to journalArticle

    31 Citations (Scopus)

    Abstract

    Cardiopulmonary bypass (CPB) is dependent on materials foreign to the patient for its successful application. When blood comes into contact with these so-called biomaterials, an inappropriate inflammatory response, which can be life-threatening in some patients, may develop. The reason for this inappropriate activation of host defence mechanisms is not entirely clear, however a number of strategies have evolved over the years to minimize this unwanted sequelae of CPB. These strategies include surface coating of the materials of the circuit, using new materials thought to improve biocompatibility, and using a number of pharmacological interventions designed to suppress the inflammatory response. Recently, there has been some evidence which indicates that the plasticizer employed in the polyvinyl chloride (PVC) tubing of the CPB circuit may play a part in the development of the inflammatory response. The work described in this paper tends to support this thesis. These studies showed that by washing the plasticizer from the surface of the PVC tubing, the biocompatibility, as reflected in the upregulation of CD11b on the surface of neutrophils, was enhanced. Furthermore, the use of non-plasticized substitutes for PVC had a similar effect. The benefit from removing the plasticizer was similar to that gained from surface coating with heparin, one of the conventional approaches to reducing the inflammatory response to CPB.
    LanguageEnglish
    Pages381-390
    Number of pages9
    JournalPerfusion
    Volume16
    Issue number5
    DOIs
    Publication statusPublished - 2001

    Fingerprint

    Biocompatible Materials
    Cardiopulmonary Bypass
    Biomaterials
    Plasticizers
    Polyvinyl Chloride
    Polyvinyl chlorides
    Tubing
    Biocompatibility
    defense mechanism
    Coatings
    activation
    Networks (circuits)
    Washing
    contact
    Heparin
    Neutrophils
    Blood
    Up-Regulation
    Chemical activation
    Pharmacology

    Keywords

    • biomaterials
    • cardiopulmonary bypass
    • bioengineering
    • surgery
    • perfusion

    Cite this

    @article{01c95ab5b09e4b8598607ea8622807d0,
    title = "Biomaterial development for cardiopulmonary bypass",
    abstract = "Cardiopulmonary bypass (CPB) is dependent on materials foreign to the patient for its successful application. When blood comes into contact with these so-called biomaterials, an inappropriate inflammatory response, which can be life-threatening in some patients, may develop. The reason for this inappropriate activation of host defence mechanisms is not entirely clear, however a number of strategies have evolved over the years to minimize this unwanted sequelae of CPB. These strategies include surface coating of the materials of the circuit, using new materials thought to improve biocompatibility, and using a number of pharmacological interventions designed to suppress the inflammatory response. Recently, there has been some evidence which indicates that the plasticizer employed in the polyvinyl chloride (PVC) tubing of the CPB circuit may play a part in the development of the inflammatory response. The work described in this paper tends to support this thesis. These studies showed that by washing the plasticizer from the surface of the PVC tubing, the biocompatibility, as reflected in the upregulation of CD11b on the surface of neutrophils, was enhanced. Furthermore, the use of non-plasticized substitutes for PVC had a similar effect. The benefit from removing the plasticizer was similar to that gained from surface coating with heparin, one of the conventional approaches to reducing the inflammatory response to CPB.",
    keywords = "biomaterials, cardiopulmonary bypass, bioengineering, surgery, perfusion",
    author = "T. Gourlay",
    year = "2001",
    doi = "10.1177/026765910101600508",
    language = "English",
    volume = "16",
    pages = "381--390",
    journal = "Perfusion",
    issn = "0267-6591",
    number = "5",

    }

    Biomaterial development for cardiopulmonary bypass. / Gourlay, T.

    In: Perfusion, Vol. 16, No. 5, 2001, p. 381-390.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Biomaterial development for cardiopulmonary bypass

    AU - Gourlay, T.

    PY - 2001

    Y1 - 2001

    N2 - Cardiopulmonary bypass (CPB) is dependent on materials foreign to the patient for its successful application. When blood comes into contact with these so-called biomaterials, an inappropriate inflammatory response, which can be life-threatening in some patients, may develop. The reason for this inappropriate activation of host defence mechanisms is not entirely clear, however a number of strategies have evolved over the years to minimize this unwanted sequelae of CPB. These strategies include surface coating of the materials of the circuit, using new materials thought to improve biocompatibility, and using a number of pharmacological interventions designed to suppress the inflammatory response. Recently, there has been some evidence which indicates that the plasticizer employed in the polyvinyl chloride (PVC) tubing of the CPB circuit may play a part in the development of the inflammatory response. The work described in this paper tends to support this thesis. These studies showed that by washing the plasticizer from the surface of the PVC tubing, the biocompatibility, as reflected in the upregulation of CD11b on the surface of neutrophils, was enhanced. Furthermore, the use of non-plasticized substitutes for PVC had a similar effect. The benefit from removing the plasticizer was similar to that gained from surface coating with heparin, one of the conventional approaches to reducing the inflammatory response to CPB.

    AB - Cardiopulmonary bypass (CPB) is dependent on materials foreign to the patient for its successful application. When blood comes into contact with these so-called biomaterials, an inappropriate inflammatory response, which can be life-threatening in some patients, may develop. The reason for this inappropriate activation of host defence mechanisms is not entirely clear, however a number of strategies have evolved over the years to minimize this unwanted sequelae of CPB. These strategies include surface coating of the materials of the circuit, using new materials thought to improve biocompatibility, and using a number of pharmacological interventions designed to suppress the inflammatory response. Recently, there has been some evidence which indicates that the plasticizer employed in the polyvinyl chloride (PVC) tubing of the CPB circuit may play a part in the development of the inflammatory response. The work described in this paper tends to support this thesis. These studies showed that by washing the plasticizer from the surface of the PVC tubing, the biocompatibility, as reflected in the upregulation of CD11b on the surface of neutrophils, was enhanced. Furthermore, the use of non-plasticized substitutes for PVC had a similar effect. The benefit from removing the plasticizer was similar to that gained from surface coating with heparin, one of the conventional approaches to reducing the inflammatory response to CPB.

    KW - biomaterials

    KW - cardiopulmonary bypass

    KW - bioengineering

    KW - surgery

    KW - perfusion

    UR - http://dx.doi.org/10.1177/026765910101600508

    U2 - 10.1177/026765910101600508

    DO - 10.1177/026765910101600508

    M3 - Article

    VL - 16

    SP - 381

    EP - 390

    JO - Perfusion

    T2 - Perfusion

    JF - Perfusion

    SN - 0267-6591

    IS - 5

    ER -