Biomarkers for dementia in Latin American countries: gaps and opportunities

Mario A. Parra; Paulina Orellana; Tomas Leon; Victoria Cabello G.; Fernando Henriquez; Rodrigo Gomez; Constanza Avalos; Andres Damian; Andrea Slachevsky; Agustin Ibañez; Henrik Zetterberg; Betty M. Tijms; Jennifer S. Yokoyama; Stefanie D.  Piña-Escudero; J. Nicholas Cochran; Diana L Matallana; Daisy Acosta; Ricardo Allegri; Bianca P. Arias-Suárez; Bernardo Barra; Maria Isabel Behrens; Sonia M. D. Brucki; Geraldo Busatto; Paulo Caramelli; Sheila Castro-Suarez; Valeria Contreras; Nilton Custodio; Sergio Dansilio; Myriam De la Cruz-Puebla; Leonardo Cruz de Souza; Monica M. Diaz; Lissette Duque; Gonzalo A. Farías; Sergio T. Ferreira; Nahuel Magrath Guimet; Ana Kmaid; David Lira; Francisco Lopera; Beatriz Mar Meza; Eliane C Miotto; Alberto Nuñez; Santiago O'neill; John Ochoa; Maritza Pintado-Caipa; Elisa de Paula França Resende; Shannon Risacher; Luz Angela Rojas; Valentina Sabaj; Lucas Schilling; Allis F. Sellek; Ana Sosa; Leonel T. Takada; Antonio L. Teixeira; Martha Unaucho-Pilalumbo; Claudia Duran-Aniotz

doi:10.1002/alz.12757

Biomarkers for dementia in Latin American countries: gaps and opportunities

Mario A. Parra, Paulina Orellana, Tomas Leon, Victoria Cabello G., Fernando Henriquez, Rodrigo Gomez, Constanza Avalos, Andres Damian, Andrea Slachevsky, Agustin Ibañez, Henrik Zetterberg, Betty M. Tijms, Jennifer S. Yokoyama, Stefanie D. Piña-Escudero, J. Nicholas Cochran, Diana L Matallana, Daisy Acosta, Ricardo Allegri, Bianca P. Arias-Suárez, Bernardo BarraMaria Isabel Behrens, Sonia M. D. Brucki, Geraldo Busatto, Paulo Caramelli, Sheila Castro-Suarez, Valeria Contreras, Nilton Custodio, Sergio Dansilio, Myriam De la Cruz-Puebla, Leonardo Cruz de Souza, Monica M. Diaz, Lissette Duque, Gonzalo A. Farías, Sergio T. Ferreira, Nahuel Magrath Guimet, Ana Kmaid, David Lira, Francisco Lopera, Beatriz Mar Meza, Eliane C Miotto, Alberto Nuñez, Santiago O'neill, John Ochoa, Maritza Pintado-Caipa, Elisa de Paula França Resende, Shannon Risacher, Luz Angela Rojas, Valentina Sabaj, Lucas Schilling, Allis F. Sellek, Ana Sosa, Leonel T. Takada, Antonio L. Teixeira, Martha Unaucho-Pilalumbo, Claudia Duran-Aniotz

Psychology

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Abstract

Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we report on the results from an online survey completed by dementia specialists from LAC. It aims to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The survey was answered by 48 respondents from 10 LAC countries. The results show that neuroimaging is the most commonly used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%) and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, we identified that lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research as the majority of respondents share an interest in the topic, would like to host studies, and confirmed access to unique populations. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to introduce and expand biomarker research and suggest strategies to accelerate such developments. These insights allowed us to propose an action plan that addresses the recommendations towards a biomarker framework recently proposed by regional experts.

Original language	English
Pages (from-to)	721-735
Journal	Alzheimer's and Dementia
Volume	19
Issue number	2
Early online date	13 Sept 2022
DOIs	https://doi.org/10.1002/alz.12757
Publication status	Published - Feb 2023

Keywords

dementia biomarkers
Latin America
barriers
research

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10.1002/alz.12757Licence: CC BY-NC 4.0

Parra-etal-AD-2022-Biomarkers-for-dementia-in-Latin-American-countriesAccepted author manuscript, 1.02 MBLicence: Strath_1
Alzheimer s Dementia - 2022 - Parra - Biomarkers for dementia in Latin American countries Gaps and opportunitiesFinal published version, 1.77 MBLicence: CC BY-NC 4.0

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Parra, M. A., Orellana, P., Leon, T., Cabello G., V., Henriquez, F., Gomez, R., Avalos, C., Damian, A., Slachevsky, A., Ibañez, A., Zetterberg, H., Tijms, B. M., Yokoyama, J. S., Piña-Escudero, S. D., Cochran, J. N., Matallana, D. L., Acosta, D., Allegri, R., Arias-Suárez, B. P., ... Duran-Aniotz, C. (2023). Biomarkers for dementia in Latin American countries: gaps and opportunities. Alzheimer's and Dementia, 19(2), 721-735. https://doi.org/10.1002/alz.12757

@article{e1121cd84c304006965b558555c8f020,

title = "Biomarkers for dementia in Latin American countries: gaps and opportunities",

abstract = "Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we report on the results from an online survey completed by dementia specialists from LAC. It aims to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The survey was answered by 48 respondents from 10 LAC countries. The results show that neuroimaging is the most commonly used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%) and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, we identified that lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research as the majority of respondents share an interest in the topic, would like to host studies, and confirmed access to unique populations. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to introduce and expand biomarker research and suggest strategies to accelerate such developments. These insights allowed us to propose an action plan that addresses the recommendations towards a biomarker framework recently proposed by regional experts. ",

keywords = "dementia biomarkers, Latin America, barriers, research",

author = "Parra, {Mario A.} and Paulina Orellana and Tomas Leon and {Cabello G.}, Victoria and Fernando Henriquez and Rodrigo Gomez and Constanza Avalos and Andres Damian and Andrea Slachevsky and Agustin Iba{\~n}ez and Henrik Zetterberg and Tijms, {Betty M.} and Yokoyama, {Jennifer S.} and Pi{\~n}a-Escudero, {Stefanie D.} and Cochran, {J. Nicholas} and Matallana, {Diana L} and Daisy Acosta and Ricardo Allegri and Arias-Su{\'a}rez, {Bianca P.} and Bernardo Barra and Behrens, {Maria Isabel} and Brucki, {Sonia M. D.} and Geraldo Busatto and Paulo Caramelli and Sheila Castro-Suarez and Valeria Contreras and Nilton Custodio and Sergio Dansilio and {De la Cruz-Puebla}, Myriam and {de Souza}, {Leonardo Cruz} and Diaz, {Monica M.} and Lissette Duque and Far{\'i}as, {Gonzalo A.} and Ferreira, {Sergio T.} and Guimet, {Nahuel Magrath} and Ana Kmaid and David Lira and Francisco Lopera and Meza, {Beatriz Mar} and Miotto, {Eliane C} and Alberto Nu{\~n}ez and Santiago O'neill and John Ochoa and Maritza Pintado-Caipa and {de Paula Fran{\c c}a Resende}, Elisa and Shannon Risacher and Rojas, {Luz Angela} and Valentina Sabaj and Lucas Schilling and Sellek, {Allis F.} and Ana Sosa and Takada, {Leonel T.} and Teixeira, {Antonio L.} and Martha Unaucho-Pilalumbo and Claudia Duran-Aniotz",

year = "2023",

month = feb,

doi = "10.1002/alz.12757",

language = "English",

volume = "19",

pages = "721--735",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

Parra, MA, Orellana, P, Leon, T, Cabello G., V, Henriquez, F, Gomez, R, Avalos, C, Damian, A, Slachevsky, A, Ibañez, A, Zetterberg, H, Tijms, BM, Yokoyama, JS, Piña-Escudero, SD, Cochran, JN, Matallana, DL, Acosta, D, Allegri, R, Arias-Suárez, BP, Barra, B, Behrens, MI, Brucki, SMD, Busatto, G, Caramelli, P, Castro-Suarez, S, Contreras, V, Custodio, N, Dansilio, S, De la Cruz-Puebla, M, de Souza, LC, Diaz, MM, Duque, L, Farías, GA, Ferreira, ST, Guimet, NM, Kmaid, A, Lira, D, Lopera, F, Meza, BM, Miotto, EC, Nuñez, A, O'neill, S, Ochoa, J, Pintado-Caipa, M, de Paula França Resende, E, Risacher, S, Rojas, LA, Sabaj, V, Schilling, L, Sellek, AF, Sosa, A, Takada, LT, Teixeira, AL, Unaucho-Pilalumbo, M & Duran-Aniotz, C 2023, 'Biomarkers for dementia in Latin American countries: gaps and opportunities', Alzheimer's and Dementia, vol. 19, no. 2, pp. 721-735. https://doi.org/10.1002/alz.12757

TY - JOUR

T1 - Biomarkers for dementia in Latin American countries

T2 - gaps and opportunities

AU - Parra, Mario A.

AU - Orellana, Paulina

AU - Leon, Tomas

AU - Cabello G., Victoria

AU - Henriquez, Fernando

AU - Gomez, Rodrigo

AU - Avalos, Constanza

AU - Damian, Andres

AU - Slachevsky, Andrea

AU - Ibañez, Agustin

AU - Zetterberg, Henrik

AU - Tijms, Betty M.

AU - Yokoyama, Jennifer S.

AU - Piña-Escudero, Stefanie D.

AU - Cochran, J. Nicholas

AU - Matallana, Diana L

AU - Acosta, Daisy

AU - Allegri, Ricardo

AU - Arias-Suárez, Bianca P.

AU - Barra, Bernardo

AU - Behrens, Maria Isabel

AU - Brucki, Sonia M. D.

AU - Busatto, Geraldo

AU - Caramelli, Paulo

AU - Castro-Suarez, Sheila

AU - Contreras, Valeria

AU - Custodio, Nilton

AU - Dansilio, Sergio

AU - De la Cruz-Puebla, Myriam

AU - de Souza, Leonardo Cruz

AU - Diaz, Monica M.

AU - Duque, Lissette

AU - Farías, Gonzalo A.

AU - Ferreira, Sergio T.

AU - Guimet, Nahuel Magrath

AU - Kmaid, Ana

AU - Lira, David

AU - Lopera, Francisco

AU - Meza, Beatriz Mar

AU - Miotto, Eliane C

AU - Nuñez, Alberto

AU - O'neill, Santiago

AU - Ochoa, John

AU - Pintado-Caipa, Maritza

AU - de Paula França Resende, Elisa

AU - Risacher, Shannon

AU - Rojas, Luz Angela

AU - Sabaj, Valentina

AU - Schilling, Lucas

AU - Sellek, Allis F.

AU - Sosa, Ana

AU - Takada, Leonel T.

AU - Teixeira, Antonio L.

AU - Unaucho-Pilalumbo, Martha

AU - Duran-Aniotz, Claudia

PY - 2023/2

Y1 - 2023/2

N2 - Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we report on the results from an online survey completed by dementia specialists from LAC. It aims to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The survey was answered by 48 respondents from 10 LAC countries. The results show that neuroimaging is the most commonly used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%) and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, we identified that lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research as the majority of respondents share an interest in the topic, would like to host studies, and confirmed access to unique populations. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to introduce and expand biomarker research and suggest strategies to accelerate such developments. These insights allowed us to propose an action plan that addresses the recommendations towards a biomarker framework recently proposed by regional experts.

AB - Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we report on the results from an online survey completed by dementia specialists from LAC. It aims to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The survey was answered by 48 respondents from 10 LAC countries. The results show that neuroimaging is the most commonly used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%) and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, we identified that lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research as the majority of respondents share an interest in the topic, would like to host studies, and confirmed access to unique populations. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to introduce and expand biomarker research and suggest strategies to accelerate such developments. These insights allowed us to propose an action plan that addresses the recommendations towards a biomarker framework recently proposed by regional experts.

KW - dementia biomarkers

KW - Latin America

KW - barriers

KW - research

UR - https://alz-journals.onlinelibrary.wiley.com/journal/15525279

U2 - 10.1002/alz.12757

DO - 10.1002/alz.12757

M3 - Article

SN - 1552-5260

VL - 19

SP - 721

EP - 735

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 2

ER -

Biomarkers for dementia in Latin American countries: gaps and opportunities

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