Projects per year
Abstract
The exchange of ammonium across cellular membranes is a fundamental process in all domains of life and is facilitated by the ubiquitous Amt/Mep/Rh transporter superfamily. Remarkably, despite a high structural conservation in all domains of life, these proteins have gained various biological functions during evolution. It is tempting to hypothesise that the physiological functions gained by these proteins may be explained at least in part by differences in the energetics of their translocation mechanisms. Therefore, in this review, we will explore our current knowledge of energetics of the Amt/Mep/Rh family, discuss variations in observations between different organisms, and highlight some technical drawbacks which have hampered effects at mechanistic characterisation. Through the review we aim to provide a comprehensive overview of current understanding of the mechanism of transport of this unique and extraordinary Amt/Mep/Rh superfamily of ammonium transporters.
Original language | English |
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Article number | BSR20211209 |
Number of pages | 24 |
Journal | Bioscience Reports |
Volume | 44 |
Issue number | 1 |
Early online date | 22 Dec 2023 |
DOIs | |
Publication status | Published - 1 Jan 2024 |
Keywords
- Amt/Mep/Rh
- ammonium transporter
- energetics
- methylamonium permease
- rhesus protein
- electrophysiology
Fingerprint
Dive into the research topics of 'Biological ammonium transporters from the Amt/Mep/Rh superfamily: mechanism, energetics, and technical limitations'. Together they form a unique fingerprint.Projects
- 3 Finished
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Functional characterisation of membrane transporters involved in human physiopathology
1/10/17 → 30/09/18
Project: Research
Research output
- 1 Citations
- 1 Review article
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Biological ammonium transporters: evolution and diversification
Williamson, G., Harris, T., Bizior, A., Hoskisson, P. A., Pritchard, L. & Javelle, A., 1 Sept 2024, In: FEBS Journal. 291, 17, p. 3786-3810 25 p.Research output: Contribution to journal › Review article › peer-review
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