Biofluid spectroscopic disease diagnostics: a review on the processes and spectral impact of drying

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

The complex patterns observed from evaporated liquid drops have been examined extensively over the last 20 years. Complete understanding of drop deposition is vital in many medical processes, and one which is essential to the translation of biofluid spectroscopic disease diagnostics. The promising use of spectroscopy in disease diagnosis has been hindered by the complicated patterns left by dried biological fluids which may inhibit the clinical translation of this technology. Coffee ring formation, cracking and gelation patterns have all been observed in biofluid drops, and with surface homogeneity being a key element to many spectroscopic techniques, experimental issues have been found to arise. A better understanding of the fundamental processes involved in a drying droplet could allow efficient progression in this research field, and ultimately benefit the population with the development of a reliable cancer diagnostic.
LanguageEnglish
Article numbere201700299
Number of pages12
JournalJournal of Biophotonics
Volume11
Issue number4
Early online date26 Jan 2018
DOIs
Publication statusPublished - 30 Apr 2018

Fingerprint

drying
Drying
Coffee
coffee
Spectrum Analysis
gelation
Technology
progressions
homogeneity
Gelation
cancer
Research
Population
Neoplasms
fluids
rings
Spectroscopy
spectroscopy
Fluids
Liquids

Keywords

  • drying
  • FTIR spectroscopy
  • disease diagnosis
  • coffee ring formation
  • wettability
  • Marangoni flow
  • serum

Cite this

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title = "Biofluid spectroscopic disease diagnostics: a review on the processes and spectral impact of drying",
abstract = "The complex patterns observed from evaporated liquid drops have been examined extensively over the last 20 years. Complete understanding of drop deposition is vital in many medical processes, and one which is essential to the translation of biofluid spectroscopic disease diagnostics. The promising use of spectroscopy in disease diagnosis has been hindered by the complicated patterns left by dried biological fluids which may inhibit the clinical translation of this technology. Coffee ring formation, cracking and gelation patterns have all been observed in biofluid drops, and with surface homogeneity being a key element to many spectroscopic techniques, experimental issues have been found to arise. A better understanding of the fundamental processes involved in a drying droplet could allow efficient progression in this research field, and ultimately benefit the population with the development of a reliable cancer diagnostic.",
keywords = "drying, FTIR spectroscopy, disease diagnosis, coffee ring formation, wettability, Marangoni flow, serum",
author = "Cameron, {James M.} and Butler, {Holly J.} and Palmer, {David S.} and Baker, {Matthew J.}",
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Biofluid spectroscopic disease diagnostics : a review on the processes and spectral impact of drying. / Cameron, James M.; Butler, Holly J.; Palmer, David S.; Baker, Matthew J.

In: Journal of Biophotonics, Vol. 11, No. 4, e201700299, 30.04.2018.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Biofluid spectroscopic disease diagnostics

T2 - Journal of Biophotonics

AU - Cameron, James M.

AU - Butler, Holly J.

AU - Palmer, David S.

AU - Baker, Matthew J.

PY - 2018/4/30

Y1 - 2018/4/30

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AB - The complex patterns observed from evaporated liquid drops have been examined extensively over the last 20 years. Complete understanding of drop deposition is vital in many medical processes, and one which is essential to the translation of biofluid spectroscopic disease diagnostics. The promising use of spectroscopy in disease diagnosis has been hindered by the complicated patterns left by dried biological fluids which may inhibit the clinical translation of this technology. Coffee ring formation, cracking and gelation patterns have all been observed in biofluid drops, and with surface homogeneity being a key element to many spectroscopic techniques, experimental issues have been found to arise. A better understanding of the fundamental processes involved in a drying droplet could allow efficient progression in this research field, and ultimately benefit the population with the development of a reliable cancer diagnostic.

KW - drying

KW - FTIR spectroscopy

KW - disease diagnosis

KW - coffee ring formation

KW - wettability

KW - Marangoni flow

KW - serum

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