Abstract
| Language | English |
|---|---|
| Article number | e201700299 |
| Number of pages | 12 |
| Journal | Journal of Biophotonics |
| Volume | 11 |
| Issue number | 4 |
| Early online date | 26 Jan 2018 |
| DOIs | |
| Publication status | Published - 30 Apr 2018 |
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Keywords
- drying
- FTIR spectroscopy
- disease diagnosis
- coffee ring formation
- wettability
- Marangoni flow
- serum
Cite this
}
Biofluid spectroscopic disease diagnostics : a review on the processes and spectral impact of drying. / Cameron, James M.; Butler, Holly J.; Palmer, David S.; Baker, Matthew J.
In: Journal of Biophotonics, Vol. 11, No. 4, e201700299, 30.04.2018.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Biofluid spectroscopic disease diagnostics
T2 - Journal of Biophotonics
AU - Cameron, James M.
AU - Butler, Holly J.
AU - Palmer, David S.
AU - Baker, Matthew J.
PY - 2018/4/30
Y1 - 2018/4/30
N2 - The complex patterns observed from evaporated liquid drops have been examined extensively over the last 20 years. Complete understanding of drop deposition is vital in many medical processes, and one which is essential to the translation of biofluid spectroscopic disease diagnostics. The promising use of spectroscopy in disease diagnosis has been hindered by the complicated patterns left by dried biological fluids which may inhibit the clinical translation of this technology. Coffee ring formation, cracking and gelation patterns have all been observed in biofluid drops, and with surface homogeneity being a key element to many spectroscopic techniques, experimental issues have been found to arise. A better understanding of the fundamental processes involved in a drying droplet could allow efficient progression in this research field, and ultimately benefit the population with the development of a reliable cancer diagnostic.
AB - The complex patterns observed from evaporated liquid drops have been examined extensively over the last 20 years. Complete understanding of drop deposition is vital in many medical processes, and one which is essential to the translation of biofluid spectroscopic disease diagnostics. The promising use of spectroscopy in disease diagnosis has been hindered by the complicated patterns left by dried biological fluids which may inhibit the clinical translation of this technology. Coffee ring formation, cracking and gelation patterns have all been observed in biofluid drops, and with surface homogeneity being a key element to many spectroscopic techniques, experimental issues have been found to arise. A better understanding of the fundamental processes involved in a drying droplet could allow efficient progression in this research field, and ultimately benefit the population with the development of a reliable cancer diagnostic.
KW - drying
KW - FTIR spectroscopy
KW - disease diagnosis
KW - coffee ring formation
KW - wettability
KW - Marangoni flow
KW - serum
UR - http://onlinelibrary.wiley.com/wol1/doi/10.1002/jbio.201700299/abstract
U2 - 10.1002/jbio.201700299
DO - 10.1002/jbio.201700299
M3 - Review article
VL - 11
JO - Journal of Biophotonics
JF - Journal of Biophotonics
SN - 1864-063X
IS - 4
M1 - e201700299
ER -