Biofluid spectroscopic disease diagnostics: a review on the processes and spectral impact of drying

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Abstract

The complex patterns observed from evaporated liquid drops have been examined extensively over the last 20 years. Complete understanding of drop deposition is vital in many medical processes, and one which is essential to the translation of biofluid spectroscopic disease diagnostics. The promising use of spectroscopy in disease diagnosis has been hindered by the complicated patterns left by dried biological fluids which may inhibit the clinical translation of this technology. Coffee ring formation, cracking and gelation patterns have all been observed in biofluid drops, and with surface homogeneity being a key element to many spectroscopic techniques, experimental issues have been found to arise. A better understanding of the fundamental processes involved in a drying droplet could allow efficient progression in this research field, and ultimately benefit the population with the development of a reliable cancer diagnostic.
Original languageEnglish
Article numbere201700299
Number of pages12
JournalJournal of Biophotonics
Volume11
Issue number4
Early online date26 Jan 2018
DOIs
Publication statusPublished - 30 Apr 2018

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Keywords

  • drying
  • FTIR spectroscopy
  • disease diagnosis
  • coffee ring formation
  • wettability
  • Marangoni flow
  • serum

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