TY - JOUR
T1 - Biofluid diagnostics by FTIR spectroscopy
T2 - a platform technology for cancer detection
AU - Sala, Alexandra
AU - Anderson, David J.
AU - Brennan, Paul M.
AU - Butler, Holly J.
AU - Cameron, James M.
AU - Jenkinson, Michael D.
AU - Rinaldi, Christopher
AU - Theakstone, Ashton G.
AU - Baker, Matthew J.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Fourier Transform Infrared Spectroscopy (FTIR) has been largely employed by scientific researchers to improve diagnosis and treatment of cancer, using various biofluids and tissues. The technology has proved to be easy to use, rapid and cost-effective for analysis on human blood serum to discriminate between cancer versus healthy control samples. The high sensitivity and specificity achievable during samples classification aided by machine learning algorithms, offers an opportunity to transform cancer referral pathways, as it has been demonstrated in a unique and recent prospective clinical validation study on brain tumours. We herein highlight the importance of early detection in cancer research using FTIR, discussing the technique, the suitability of serum for analysis and previous studies, with special focus on pre-clinical factors and clinical translation requirements and development.
AB - Fourier Transform Infrared Spectroscopy (FTIR) has been largely employed by scientific researchers to improve diagnosis and treatment of cancer, using various biofluids and tissues. The technology has proved to be easy to use, rapid and cost-effective for analysis on human blood serum to discriminate between cancer versus healthy control samples. The high sensitivity and specificity achievable during samples classification aided by machine learning algorithms, offers an opportunity to transform cancer referral pathways, as it has been demonstrated in a unique and recent prospective clinical validation study on brain tumours. We herein highlight the importance of early detection in cancer research using FTIR, discussing the technique, the suitability of serum for analysis and previous studies, with special focus on pre-clinical factors and clinical translation requirements and development.
KW - ATR-FTIR
KW - biofluids
KW - brain tumour
KW - cancer
KW - early detection
KW - infrared spectroscopy
KW - serum
UR - http://www.scopus.com/inward/record.url?scp=85082125097&partnerID=8YFLogxK
U2 - 10.1016/j.canlet.2020.02.020
DO - 10.1016/j.canlet.2020.02.020
M3 - Review article
C2 - 32112901
AN - SCOPUS:85082125097
VL - 477
SP - 122
EP - 130
ER -