Biofluid diagnostics by FTIR spectroscopy: a platform technology for cancer detection

Alexandra Sala, David J. Anderson, Paul M. Brennan, Holly J. Butler, James M. Cameron, Michael D. Jenkinson, Christopher Rinaldi, Ashton G. Theakstone, Matthew J. Baker

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)
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Abstract

Fourier Transform Infrared Spectroscopy (FTIR) has been largely employed by scientific researchers to improve diagnosis and treatment of cancer, using various biofluids and tissues. The technology has proved to be easy to use, rapid and cost-effective for analysis on human blood serum to discriminate between cancer versus healthy control samples. The high sensitivity and specificity achievable during samples classification aided by machine learning algorithms, offers an opportunity to transform cancer referral pathways, as it has been demonstrated in a unique and recent prospective clinical validation study on brain tumours. We herein highlight the importance of early detection in cancer research using FTIR, discussing the technique, the suitability of serum for analysis and previous studies, with special focus on pre-clinical factors and clinical translation requirements and development.

Original languageEnglish
Pages (from-to)122-130
Number of pages9
JournalCancer Letters
Volume477
Early online date26 Feb 2020
DOIs
Publication statusPublished - 1 May 2020

Keywords

  • ATR-FTIR
  • biofluids
  • brain tumour
  • cancer
  • early detection
  • infrared spectroscopy
  • serum

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