Biofluid diagnostics by FTIR spectroscopy: a platform technology for cancer detection

Alexandra Sala; David J. Anderson; Paul M. Brennan; Holly J. Butler; James M. Cameron; Michael D. Jenkinson; Christopher Rinaldi; Ashton G. Theakstone; Matthew J. Baker

doi:10.1016/j.canlet.2020.02.020

Biofluid diagnostics by FTIR spectroscopy: a platform technology for cancer detection

Alexandra Sala, David J. Anderson, Paul M. Brennan, Holly J. Butler, James M. Cameron, Michael D. Jenkinson, Christopher Rinaldi, Ashton G. Theakstone, Matthew J. Baker^*

^*Corresponding author for this work

Pure And Applied Chemistry

Research output: Contribution to journal › Review article › peer-review

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Abstract

Fourier Transform Infrared Spectroscopy (FTIR) has been largely employed by scientific researchers to improve diagnosis and treatment of cancer, using various biofluids and tissues. The technology has proved to be easy to use, rapid and cost-effective for analysis on human blood serum to discriminate between cancer versus healthy control samples. The high sensitivity and specificity achievable during samples classification aided by machine learning algorithms, offers an opportunity to transform cancer referral pathways, as it has been demonstrated in a unique and recent prospective clinical validation study on brain tumours. We herein highlight the importance of early detection in cancer research using FTIR, discussing the technique, the suitability of serum for analysis and previous studies, with special focus on pre-clinical factors and clinical translation requirements and development.

Original language	English
Pages (from-to)	122-130
Number of pages	9
Journal	Cancer Letters
Volume	477
Early online date	26 Feb 2020
DOIs	https://doi.org/10.1016/j.canlet.2020.02.020
Publication status	Published - 1 May 2020

Funding

The authors would like to thank the EPSRC ( EP/L505080/1 ), Scottish Enterprise and ClinSpec Diagnostics Ltd for funding.

Keywords

ATR-FTIR
biofluids
brain tumour
cancer
early detection
infrared spectroscopy
serum

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10.1016/j.canlet.2020.02.020

Sala-etal-CL-2020-Biofluid-diagnostics-by-FTIR-spectroscopyAccepted author manuscript, 1.46 MBLicence: CC BY-NC-ND 4.0

Cite this

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title = "Biofluid diagnostics by FTIR spectroscopy: a platform technology for cancer detection",

abstract = "Fourier Transform Infrared Spectroscopy (FTIR) has been largely employed by scientific researchers to improve diagnosis and treatment of cancer, using various biofluids and tissues. The technology has proved to be easy to use, rapid and cost-effective for analysis on human blood serum to discriminate between cancer versus healthy control samples. The high sensitivity and specificity achievable during samples classification aided by machine learning algorithms, offers an opportunity to transform cancer referral pathways, as it has been demonstrated in a unique and recent prospective clinical validation study on brain tumours. We herein highlight the importance of early detection in cancer research using FTIR, discussing the technique, the suitability of serum for analysis and previous studies, with special focus on pre-clinical factors and clinical translation requirements and development.",

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T2 - a platform technology for cancer detection

AU - Sala, Alexandra

AU - Anderson, David J.

AU - Brennan, Paul M.

AU - Butler, Holly J.

AU - Cameron, James M.

AU - Jenkinson, Michael D.

AU - Rinaldi, Christopher

AU - Theakstone, Ashton G.

AU - Baker, Matthew J.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Fourier Transform Infrared Spectroscopy (FTIR) has been largely employed by scientific researchers to improve diagnosis and treatment of cancer, using various biofluids and tissues. The technology has proved to be easy to use, rapid and cost-effective for analysis on human blood serum to discriminate between cancer versus healthy control samples. The high sensitivity and specificity achievable during samples classification aided by machine learning algorithms, offers an opportunity to transform cancer referral pathways, as it has been demonstrated in a unique and recent prospective clinical validation study on brain tumours. We herein highlight the importance of early detection in cancer research using FTIR, discussing the technique, the suitability of serum for analysis and previous studies, with special focus on pre-clinical factors and clinical translation requirements and development.

AB - Fourier Transform Infrared Spectroscopy (FTIR) has been largely employed by scientific researchers to improve diagnosis and treatment of cancer, using various biofluids and tissues. The technology has proved to be easy to use, rapid and cost-effective for analysis on human blood serum to discriminate between cancer versus healthy control samples. The high sensitivity and specificity achievable during samples classification aided by machine learning algorithms, offers an opportunity to transform cancer referral pathways, as it has been demonstrated in a unique and recent prospective clinical validation study on brain tumours. We herein highlight the importance of early detection in cancer research using FTIR, discussing the technique, the suitability of serum for analysis and previous studies, with special focus on pre-clinical factors and clinical translation requirements and development.

KW - ATR-FTIR

KW - biofluids

KW - brain tumour

KW - cancer

KW - early detection

KW - infrared spectroscopy

KW - serum

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DO - 10.1016/j.canlet.2020.02.020

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SN - 0304-3835

VL - 477

SP - 122

EP - 130

JO - Cancer Letters

JF - Cancer Letters

ER -

Biofluid diagnostics by FTIR spectroscopy: a platform technology for cancer detection

Abstract

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Keywords

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